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10.1038/ncomms6277 http://scihub22266oqcxt.onion/10.1038/ncomms6277 C5036525!5036525!25358478     free     free     free       Nat+Commun 2014 ; 5 (ä): 5277 Nephropedia Template TP {{tp|p=25358478|t=2014. Universal database search tool for proteomics |pdf=|usr=}}{{25358478}} gab.com Text Universal database search tool for proteomics JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25358478 #FOAvip Mass spectrometry (MS) instruments and experimental protocols are rapidly advancing, but the software tools to analyze tandem mass spectra are lagging behind. We present a database search tool MS-GF+ that is sensitive (it identifies more peptides than most other database search tools) and universal (it works well for diverse types of spectra, different configurations of MS instruments and different experimental protocols). We benchmark MS-GF+ using diverse spectral datasets: (i) spectra of varying fragmentation methods; (ii) spectra of multiple enzyme digests; (iii) spectra of phosphorylated peptides; (iv) spectra of peptides with unusual fragmentation propensities produced by a novel alpha-lytic protease. For all these datasets, MS-GF+ significantly increases the number of identified peptides compared to commonly used methods for peptide identifications. We emphasize that while MS-GF+ is not specifically designed for any particular experimental set-up, it improves upon the performance of tools specifically designed for these applications (e.g., specialized tools for phosphoproteomics). Twit Text FOAVip Universal database search tool for proteomics ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25358478 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25358478 #FOAvip English Wikipedia <ref>{{Cite pmid|25358478}}</ref> Universal database search tool for proteomics #MMPMID25358478 Kim S; Pevzner PA Nat Commun 2014[]; 5 (ä): 5277 PMID25358478show ga Mass spectrometry (MS) instruments and experimental protocols are rapidly advancing, but the software tools to analyze tandem mass spectra are lagging behind. We present a database search tool MS-GF+ that is sensitive (it identifies more peptides than most other database search tools) and universal (it works well for diverse types of spectra, different configurations of MS instruments and different experimental protocols). We benchmark MS-GF+ using diverse spectral datasets: (i) spectra of varying fragmentation methods; (ii) spectra of multiple enzyme digests; (iii) spectra of phosphorylated peptides; (iv) spectra of peptides with unusual fragmentation propensities produced by a novel alpha-lytic protease. For all these datasets, MS-GF+ significantly increases the number of identified peptides compared to commonly used methods for peptide identifications. We emphasize that while MS-GF+ is not specifically designed for any particular experimental set-up, it improves upon the performance of tools specifically designed for these applications (e.g., specialized tools for phosphoproteomics). äUniversal database search tool for proteomics (epmc).pdf DeepDyve Pubget Overpricing