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10.1073/pnas.1611751113 http://scihub22266oqcxt.onion/10.1073/pnas.1611751113 C5035883!5035883 !27601648     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27601648 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27601648 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (38 ): 10625-30 Nephropedia Template TP {{tp|p=27601648 |t=2016. Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production |pdf=|usr=}}{{27601648 }} gab.com Text Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27601648 #FOAvip Immunomodulatory drugs (IMiDs) are a family of compounds derived from thalidomide. Binding of the IMiD molecule to the Lon protease Cereblon initiates the degradation of substrates via the ubiquitin proteasome pathway. Here, we show that Cereblon forms a complex with Rabex-5, a regulator of immune homeostasis. Treatment with lenalidomide prevented the association of Cereblon with Rabex-5. Conversely, mutation of the IMiD binding site increased Cereblon-Rabex-5 coimmunoprecipitation. The thalidomide binding region of Cereblon therefore regulates the formation of this complex. Knockdown of Rabex-5 in the THP-1 macrophage cell line up-regulated Toll-like receptor (TLR)-induced cytokine and type 1 IFN production via a STAT1/IRF activating pathway. Thus, we identify Rabex-5 as a IMiD target molecule that functions to restrain TLR activated auto-immune promoting pathways. We propose that release of Rabex-5 from complex with Cereblon enables the suppression of immune responses, contributing to the antiinflammatory properties of IMiDs. Twit Text FOAVip Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27601648 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27601648 #FOAvip English Wikipedia <ref>{{Cite pmid|27601648 }}</ref> Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production #MMPMID27601648 Millrine D ; Tei M ; Gemechu Y ; Kishimoto T Proc Natl Acad Sci U S A 2016[Sep]; 113 (38 ): 10625-30 PMID27601648 show ga Immunomodulatory drugs (IMiDs) are a family of compounds derived from thalidomide. Binding of the IMiD molecule to the Lon protease Cereblon initiates the degradation of substrates via the ubiquitin proteasome pathway. Here, we show that Cereblon forms a complex with Rabex-5, a regulator of immune homeostasis. Treatment with lenalidomide prevented the association of Cereblon with Rabex-5. Conversely, mutation of the IMiD binding site increased Cereblon-Rabex-5 coimmunoprecipitation. The thalidomide binding region of Cereblon therefore regulates the formation of this complex. Knockdown of Rabex-5 in the THP-1 macrophage cell line up-regulated Toll-like receptor (TLR)-induced cytokine and type 1 IFN production via a STAT1/IRF activating pathway. Thus, we identify Rabex-5 as a IMiD target molecule that functions to restrain TLR activated auto-immune promoting pathways. We propose that release of Rabex-5 from complex with Cereblon enables the suppression of immune responses, contributing to the antiinflammatory properties of IMiDs. |Adaptor Proteins, Signal Transducing [MESH] |Binding Sites/drug effects [MESH] |Gene Knockdown Techniques [MESH] |Guanine Nucleotide Exchange Factors/genetics/*metabolism [MESH] |Humans [MESH] |Immunity, Cellular/drug effects/*genetics [MESH] |Immunologic Factors/pharmacology [MESH] |Interferon Type I/biosynthesis/*genetics [MESH] |Lenalidomide [MESH] |Multiprotein Complexes/drug effects/genetics [MESH] |Peptide Hydrolases/genetics/*metabolism [MESH] |Protein Binding/drug effects [MESH] |Thalidomide/analogs & derivatives/pharmacology [MESH] |Toll-Like Receptors/genetics/metabolism [MESH]Rabex-5 is a lenalidomide target molecule that negatively regulates TL(epmc).pdf DeepDyve Pubget Overpricing