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10.1002/eji.201545550 http://scihub22266oqcxt.onion/10.1002/eji.201545550 C5035674!5035674!27230488     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2016 ; 46 (7): 1548-62 Nephropedia Template TP {{tp|p=27230488|t=2016. GENERATING LONG-LIVED CD8 T CELL MEMORY: INSIGHTS FROM EPIGENETIC PROGRAMS |pdf=|usr=}}{{27230488}} gab.com Text GENERATING LONG-LIVED CD8 T CELL MEMORY: INSIGHTS FROM EPIGENETIC PROGRAMS JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27230488 #FOAvip T cell based immunological memory has the potential to provide the host with life-long protection against pathogen re-exposure and thus offers tremendous promise for the design of vaccines targeting chronic infections or cancer. In order to exploit this potential in the design of new vaccines it is necessary to understand how and when memory T cells acquire their poised effector potential, and moreover, how they maintain these properties during homeostatic proliferation. To gain insight into the persistent nature of memory T cell functions, investigators have turned their attention to epigenetic mechanisms. Recent efforts have revealed that many of the properties acquired among memory T cells are coupled to stable changes in DNA methylation and histone modifications. Furthermore, it has recently been reported that the delineating features among memory T cells subsets are also linked to distinct epigenetic events providing exciting new hypotheses regarding their cellular ancestry. Here we review recent studies focused on epigenetic programs acquired during effector and memory T cell differentiation and discuss how these data may shed new light on the developmental path for generating long-lived CD8 T cell memory. Twit Text FOAVip GENERATING LONG-LIVED CD8 T CELL MEMORY: INSIGHTS FROM EPIGENETIC PROGRAMS ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27230488 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27230488 #FOAvip English Wikipedia <ref>{{Cite pmid|27230488}}</ref> GENERATING LONG-LIVED CD8 T CELL MEMORY: INSIGHTS FROM EPIGENETIC PROGRAMS #MMPMID27230488 Dogra P; Ghoneim HE; Abdelsamed HA; Youngblood B Eur J Immunol 2016[Jul]; 46 (7): 1548-62 PMID27230488show ga T cell based immunological memory has the potential to provide the host with life-long protection against pathogen re-exposure and thus offers tremendous promise for the design of vaccines targeting chronic infections or cancer. In order to exploit this potential in the design of new vaccines it is necessary to understand how and when memory T cells acquire their poised effector potential, and moreover, how they maintain these properties during homeostatic proliferation. To gain insight into the persistent nature of memory T cell functions, investigators have turned their attention to epigenetic mechanisms. Recent efforts have revealed that many of the properties acquired among memory T cells are coupled to stable changes in DNA methylation and histone modifications. Furthermore, it has recently been reported that the delineating features among memory T cells subsets are also linked to distinct epigenetic events providing exciting new hypotheses regarding their cellular ancestry. Here we review recent studies focused on epigenetic programs acquired during effector and memory T cell differentiation and discuss how these data may shed new light on the developmental path for generating long-lived CD8 T cell memory. äGENERATING LONG-LIVED CD8 T CELL MEMORY: INSIGHTS FROM EPIGENETIC PROG(epmc).pdf DeepDyve Pubget Overpricing