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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Arterioscler+Thromb+Vasc+Biol 2016 ; 36 (10): 2048-57 Nephropedia Template TP
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Endothelial Cell Junctional Adhesion Molecules: Role and Regulation of Expression in Inflammation #MMPMID27515379
Reglero-Real N; Colom B; Bodkin JV; Nourshargh S
Arterioscler Thromb Vasc Biol 2016[Oct]; 36 (10): 2048-57 PMID27515379show ga
Endothelial cells (ECs) line the lumen of all blood vessels and play a critical role in maintaining the barrier function of the vasculature. Sealing of the vessel wall between adjacent ECs is facilitated by interactions involving junctionally expressed transmembrane proteins including tight junctional molecules, such as members of the junctional adhesion molecule (JAM) family, components of adherence junctions, such as VE-Cadherin, and other molecules such as platelet endothelial cell adhesion molecule (PECAM). Of importance, a growing body of evidence indicates that the expression of these molecules is regulated in a spatiotemporal manner during inflammation; responses that have significant implications for the barrier function of blood vessels against blood-borne macromolecules and transmigrating leukocytes. This review summarises key aspects of our current understanding of the dynamics and mechanisms that regulate the expression of EC junctional molecules during inflammation, and discusses the associated functional implications of such events in acute and chronic scenarios.