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10.1016/S0377-1237(08)80009-3

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suck abstract from ncbi


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pmid27688567      Med+J+Armed+Forces+India 2008 ; 64 (4): 320-4
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  • Use of Anti-Craving Agents in Soldiers with Alcohol Dependence Syndrome #MMPMID27688567
  • Narayana P; Gupta A; Sharma P
  • Med J Armed Forces India 2008[Oct]; 64 (4): 320-4 PMID27688567show ga
  • Background: In a search for an effective ?anti-alcohol pill?, three modern anti-craving agents have been studied in alcoholics of Army/ DSC, Air Force, Navy and Coast Guard. Methods: 129 patients of alcohol dependence syndrome were randomly assigned to three groups where topiramate, acamprosate and naltrexone were used as anti-craving agents in a year long prospective study. Of these 92 patients completed the study. Result and Conclusion: Topiramate (76.3%) appears to be significantly more effective (p<0.01) in sustaining abstinence, though naltrexone (57.7%) and acamprosate (60.70%) offer moderate relapse-prevention efficacy. Side effects of all the three agents have been mild, transient and self-limiting. We recommend a trial of topiramate, before invaliding out of any alcoholic soldier.
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