"Targeting astrocytes in CNS injury and disease: A translational research
approach"
#MMPMID27026202
Filous AR
; Silver J
Prog Neurobiol
2016[Sep]; 144
(?): 173-87
PMID27026202
show ga
Astrocytes are a major constituent of the central nervous system. These glia play
a major role in regulating blood-brain barrier function, the formation and
maintenance of synapses, glutamate uptake, and trophic support for surrounding
neurons and glia. Therefore, maintaining the proper functioning of these cells is
crucial to survival. Astrocyte defects are associated with a wide variety of
neuropathological insults, ranging from neurodegenerative diseases to gliomas.
Additionally, injury to the CNS causes drastic changes to astrocytes, often
leading to a phenomenon known as reactive astrogliosis. This process is important
for protecting the surrounding healthy tissue from the spread of injury, while it
also inhibits axonal regeneration and plasticity. Here, we discuss the important
roles of astrocytes after injury and in disease, as well as potential therapeutic
approaches to restore proper astrocyte functioning.
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