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10.1038/srep33692 http://scihub22266oqcxt.onion/10.1038/srep33692 C5034251!5034251!27659682     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2016 ; 6 (ä): ä Nephropedia Template TP {{tp|p=27659682|t=2016. Transmission of survival signals through Delta-like 1 on activated CD4+ T cells |pdf=|usr=}}{{27659682}} gab.com Text Transmission of survival signals through Delta-like 1 on activated CD4+ T cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27659682 #FOAvip Notch expressed on CD4+ T cells transduces signals that mediate their effector functions and survival. Although Notch signaling is known to be cis-inhibited by Notch ligands expressed on the same cells, the role of Notch ligands on T cells remains unclear. In this report we demonstrate that the CD4+ T cell Notch ligand Dll1 transduces signals required for their survival. Co-transfer of CD4+ T cells from Dll1?/? and control mice into recipient mice followed by immunization revealed a rapid decline of CD4+ T cells from Dll1?/? mice compared with control cells. Dll1?/? mice exhibited lower clinical scores of experimental autoimmune encephalitis than control mice. The expression of Notch target genes in CD4+ T cells from Dll1?/? mice was not affected, suggesting that Dll1 deficiency in T cells does not affect cis Notch signaling. Overexpression of the intracellular domain of Dll1 in Dll1-deficient CD4+ T cells partially rescued impaired survival. Our data demonstrate that Dll1 is an independent regulator of Notch-signaling important for the survival of activated CD4+ T cells, and provide new insight into the physiological roles of Notch ligands as well as a regulatory mechanism important for maintaining adaptive immune responses. Twit Text FOAVip Transmission of survival signals through Delta-like 1 on activated CD4+ T cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27659682 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27659682 #FOAvip English Wikipedia <ref>{{Cite pmid|27659682}}</ref> Transmission of survival signals through Delta-like 1 on activated CD4+ T cells #MMPMID27659682 Furukawa T; Ishifune C; Tsukumo Si; Hozumi K; Maekawa Y; Matsui N; Kaji R; Yasutomo K Sci Rep 2016[]; 6 (ä): ä PMID27659682show ga Notch expressed on CD4+ T cells transduces signals that mediate their effector functions and survival. Although Notch signaling is known to be cis-inhibited by Notch ligands expressed on the same cells, the role of Notch ligands on T cells remains unclear. In this report we demonstrate that the CD4+ T cell Notch ligand Dll1 transduces signals required for their survival. Co-transfer of CD4+ T cells from Dll1?/? and control mice into recipient mice followed by immunization revealed a rapid decline of CD4+ T cells from Dll1?/? mice compared with control cells. Dll1?/? mice exhibited lower clinical scores of experimental autoimmune encephalitis than control mice. The expression of Notch target genes in CD4+ T cells from Dll1?/? mice was not affected, suggesting that Dll1 deficiency in T cells does not affect cis Notch signaling. Overexpression of the intracellular domain of Dll1 in Dll1-deficient CD4+ T cells partially rescued impaired survival. Our data demonstrate that Dll1 is an independent regulator of Notch-signaling important for the survival of activated CD4+ T cells, and provide new insight into the physiological roles of Notch ligands as well as a regulatory mechanism important for maintaining adaptive immune responses. äTransmission of survival signals through Delta-like 1 on activated CD4(epmc).pdf DeepDyve Pubget Overpricing