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10.1093/rheumatology/kew262 http://scihub22266oqcxt.onion/10.1093/rheumatology/kew262 C5034220!5034220 !27354683     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27354683 &cmd=llinks): Failed to open stream: HTTP request failed! 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Interferon ? kinoid induces neutralizing anti-interferon ? antibodies that decrease the expression of interferon-induced and B cell activation associated transcripts: analysis of extended follow-up data from the interferon ? kinoid phase I/II study |pdf=|usr=}}{{27354683 }} gab.com Text Interferon kinoid induces neutralizing anti-interferon antibodies that decrease the expression of interferon-induced and B cell activation associated transcripts: analysis of extended follow-up data from the interferon kinoid phase I/II study JO: Rheumatology (Oxford) http://www.kidney.de/pget.php?&tw=1&pmid=27354683 #FOAvip OBJECTIVE: IFN ? Kinoid (IFN-K) is a therapeutic vaccine composed of IFN?2b coupled to a carrier protein. In a phase I/II placebo-controlled trial, we observed that IFN-K significantly decreases the IFN gene signature in whole blood RNA samples from SLE patients. Here, we analysed extended follow-up data from IFN-K-treated patients, in order to evaluate persistence of neutralizing anti-IFN? Abs antibodies (Abs), and gene expression profiling. METHODS: Serum and whole blood RNA samples were obtained in IFN-K-treated patients included in the follow-up study, in order to determine binding and neutralizing anti-IFN? Ab titres, and perform high-throughput transcriptomic studies. RESULTS: Neutralization studies of 13 IFN? subtypes demonstrated the polyclonal nature of the Ab response induced by IFN-K. Follow-up analyses in six patients confirmed a significant correlation between neutralizing anti-IFN? Ab titres and decrease in IFN scores compared to baseline. These analyses also revealed an inhibitory effect of IFN? blockade on the expression of B cell associated transcripts. CONCLUSIONS: IFN-K induces a polyclonal anti-IFN? response that decreases IFN- and B cell-associated transcripts. TRIAL REGISTRATION: ClinicalTrials.gov, clinicaltrials.gov, NCT01058343. Twit Text FOAVip Interferon kinoid induces neutralizing anti-interferon antibodies that decrease the expression of interferon-induced and B cell activation associated transcripts: analysis of extended follow-up data from the interferon kinoid phase I/II study ????Rheumatology (Oxford) http://www.kidney.de/pget.php?&tw=1&pmid=27354683 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27354683 #FOAvip English Wikipedia <ref>{{Cite pmid|27354683 }}</ref> Interferon ? kinoid induces neutralizing anti-interferon ? antibodies that decrease the expression of interferon-induced and B cell activation associated transcripts: analysis of extended follow-up data from the interferon ? kinoid phase I/II study #MMPMID27354683 Ducreux J ; Houssiau FA ; Vandepapelière P ; Jorgensen C ; Lazaro E ; Spertini F ; Colaone F ; Roucairol C ; Laborie M ; Croughs T ; Grouard-Vogel G ; Lauwerys BR Rheumatology (Oxford) 2016[Oct]; 55 (10 ): 1901-5 PMID27354683 show ga OBJECTIVE: IFN ? Kinoid (IFN-K) is a therapeutic vaccine composed of IFN?2b coupled to a carrier protein. In a phase I/II placebo-controlled trial, we observed that IFN-K significantly decreases the IFN gene signature in whole blood RNA samples from SLE patients. Here, we analysed extended follow-up data from IFN-K-treated patients, in order to evaluate persistence of neutralizing anti-IFN? Abs antibodies (Abs), and gene expression profiling. METHODS: Serum and whole blood RNA samples were obtained in IFN-K-treated patients included in the follow-up study, in order to determine binding and neutralizing anti-IFN? Ab titres, and perform high-throughput transcriptomic studies. RESULTS: Neutralization studies of 13 IFN? subtypes demonstrated the polyclonal nature of the Ab response induced by IFN-K. Follow-up analyses in six patients confirmed a significant correlation between neutralizing anti-IFN? Ab titres and decrease in IFN scores compared to baseline. These analyses also revealed an inhibitory effect of IFN? blockade on the expression of B cell associated transcripts. CONCLUSIONS: IFN-K induces a polyclonal anti-IFN? response that decreases IFN- and B cell-associated transcripts. TRIAL REGISTRATION: ClinicalTrials.gov, clinicaltrials.gov, NCT01058343. |Adolescent [MESH] |Adult [MESH] |Anti-Inflammatory Agents/*administration & dosage [MESH] |Antibodies, Neutralizing/*immunology [MESH] |B-Lymphocytes/*immunology [MESH] |Dose-Response Relationship, Drug [MESH] |Double-Blind Method [MESH] |Female [MESH] |Follow-Up Studies [MESH] |Humans [MESH] |Interferon alpha-2 [MESH] |Interferon-alpha/*administration & dosage/immunology [MESH] |Lupus Erythematosus, Systemic/*drug therapy/immunology [MESH] |Lymphocyte Activation/immunology [MESH] |Male [MESH] |Middle Aged [MESH] |Recombinant Proteins/administration & dosage [MESH]Interferon ? kinoid induces neutralizing anti-interferon ? antibodies (epmc).pdf DeepDyve Pubget Overpricing