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10.1172/jci.insight.85311 http://scihub22266oqcxt.onion/10.1172/jci.insight.85311 C5033865!5033865 !27699254     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27699254 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       JCI+Insight 2016 ; 1 (2 ): e85311 Nephropedia Template TP {{tp|p=27699254 |t=2016. Dynamic dual-isotope molecular imaging elucidates principles for optimizing intrathecal drug delivery |pdf=|usr=}}{{27699254 }} gab.com Text Dynamic dual-isotope molecular imaging elucidates principles for optimizing intrathecal drug delivery JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=27699254 #FOAvip The intrathecal (IT) dosing route offers a seemingly obvious solution for delivering drugs directly to the central nervous system. However, gaps in understanding drug molecule behavior within the anatomically and kinetically unique environment of the mammalian IT space have impeded the establishment of pharmacokinetic principles for optimizing regional drug exposure along the neuraxis. Here, we have utilized high-resolution single-photon emission tomography with X-ray computed tomography to study the behavior of multiple molecular imaging tracers following an IT bolus injection, with supporting histology, autoradiography, block-face tomography, and MRI. Using simultaneous dual-isotope imaging, we demonstrate that the regional CNS tissue exposure of molecules with varying chemical properties is affected by IT space anatomy, cerebrospinal fluid (CSF) dynamics, CSF clearance routes, and the location and volume of the injected bolus. These imaging approaches can be used across species to optimize the safety and efficacy of IT drug therapy for neurological disorders. Twit Text FOAVip Dynamic dual-isotope molecular imaging elucidates principles for optimizing intrathecal drug delivery ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=27699254 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27699254 #FOAvip English Wikipedia <ref>{{Cite pmid|27699254 }}</ref> Dynamic dual-isotope molecular imaging elucidates principles for optimizing intrathecal drug delivery #MMPMID27699254 Wolf DA ; Hesterman JY ; Sullivan JM ; Orcutt KD ; Silva MD ; Lobo M ; Wellman T ; Hoppin J ; Verma A JCI Insight 2016[Feb]; 1 (2 ): e85311 PMID27699254 show ga The intrathecal (IT) dosing route offers a seemingly obvious solution for delivering drugs directly to the central nervous system. However, gaps in understanding drug molecule behavior within the anatomically and kinetically unique environment of the mammalian IT space have impeded the establishment of pharmacokinetic principles for optimizing regional drug exposure along the neuraxis. Here, we have utilized high-resolution single-photon emission tomography with X-ray computed tomography to study the behavior of multiple molecular imaging tracers following an IT bolus injection, with supporting histology, autoradiography, block-face tomography, and MRI. Using simultaneous dual-isotope imaging, we demonstrate that the regional CNS tissue exposure of molecules with varying chemical properties is affected by IT space anatomy, cerebrospinal fluid (CSF) dynamics, CSF clearance routes, and the location and volume of the injected bolus. These imaging approaches can be used across species to optimize the safety and efficacy of IT drug therapy for neurological disorders. |*Drug Delivery Systems [MESH] |*Injections, Spinal [MESH] |*Molecular Imaging [MESH] |Animals [MESH] |Central Nervous System/*diagnostic imaging [MESH] |Cerebrospinal Fluid [MESH] |Humans [MESH] |Isotopes [MESH] |Magnetic Resonance Imaging [MESH] |Positron-Emission Tomography [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH] |Serum Albumin, Human [MESH] |Tomography, Emission-Computed, Single-Photon [MESH]Dynamic dual-isotope molecular imaging elucidates principles for optim(epmc).pdf DeepDyve Pubget Overpricing