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10.1158/0008-5472.CAN-15-3073 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-15-3073 C5033679!5033679!27246830     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2016 ; 76 (14): 4293-304 Nephropedia Template TP {{tp|p=27246830|t=2016. miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis |pdf=|usr=}}{{27246830}} gab.com Text miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27246830 #FOAvip Malignant glioma is an often fatal type of cancer. Aberrant activation of STAT3 leads to glioma tumorigenesis. STAT3- induced transcription of protein-coding genes has been extensively studied; however, little is known about STAT3-regulated miRNA gene transcription in glioma tumorigenesis. In this study, we found that abnormal activation or decreased expression of STAT3 promotes or inhibits the expression of miR-182- 5p, respectively. Bioinformatics analyses determined that tumor suppressor protocadherin-8 (PCDH8) is a candidate target gene of miR-182-5p. miR-182-5p negatively regulated PCDH8 expression by directly targeting its 3'-untranslated region. PCDH8 knockdown induced the proliferative and invasive capacities of glioma cells. Silencing of PCDH8 or miR-182-5p mimics could reverse the inhibitory effect of WP1066, a STAT3 inhibitor, or STAT3 knockdown in vitro and in vivo on glioma progression. Clinically, expression levels of PCDH8 were inversely correlated with those of p- STAT3 or miR-182-5p in glioblastoma tissues. These findings reveal that the STAT3/miR-182-5p/PCDH8 axis has a critical role in glioma tumorigenesis and that targeting the axis may provide a new therapeutic approach for human glioma. Twit Text FOAVip miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27246830 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27246830 #FOAvip English Wikipedia <ref>{{Cite pmid|27246830}}</ref> miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis #MMPMID27246830 Xue J; Zhou A; Wu Y; Morris SA; Lin K; Amin S; Verhaak R; Fuller G; Xie K; Heimberger AB; Huang S Cancer Res 2016[Jul]; 76 (14): 4293-304 PMID27246830show ga Malignant glioma is an often fatal type of cancer. Aberrant activation of STAT3 leads to glioma tumorigenesis. STAT3- induced transcription of protein-coding genes has been extensively studied; however, little is known about STAT3-regulated miRNA gene transcription in glioma tumorigenesis. In this study, we found that abnormal activation or decreased expression of STAT3 promotes or inhibits the expression of miR-182- 5p, respectively. Bioinformatics analyses determined that tumor suppressor protocadherin-8 (PCDH8) is a candidate target gene of miR-182-5p. miR-182-5p negatively regulated PCDH8 expression by directly targeting its 3'-untranslated region. PCDH8 knockdown induced the proliferative and invasive capacities of glioma cells. Silencing of PCDH8 or miR-182-5p mimics could reverse the inhibitory effect of WP1066, a STAT3 inhibitor, or STAT3 knockdown in vitro and in vivo on glioma progression. Clinically, expression levels of PCDH8 were inversely correlated with those of p- STAT3 or miR-182-5p in glioblastoma tissues. These findings reveal that the STAT3/miR-182-5p/PCDH8 axis has a critical role in glioma tumorigenesis and that targeting the axis may provide a new therapeutic approach for human glioma. ämiR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis (epmc).pdf DeepDyve Pubget Overpricing