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2016 ; 2016
(ä): 8582362
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Corneal Epithelial Remodeling and Its Effect on Corneal Asphericity after
Transepithelial Photorefractive Keratectomy for Myopia
#MMPMID27672447
Hou J
; Wang Y
; Lei Y
; Zheng X
; Zhang Y
J Ophthalmol
2016[]; 2016
(ä): 8582362
PMID27672447
show ga
Purpose. To evaluate the changes in epithelial thickness profile following
transepithelial photorefractive keratectomy (T-PRK) for myopia and to investigate
the effect of epithelial remodeling on corneal asphericity. Methods. Forty-four
patients (44 right eyes) who underwent T-PRK were retrospectively evaluated.
Epithelial thickness was measured using spectral-domain optical coherence
tomography at different corneal zones (central, 2?mm; paracentral, 2-5?mm; and
mid-peripheral, 5-6?mm) preoperatively and at 1 week and 1, 3, and 6 months
postoperatively. The correlation between the changes in corneal epithelial
thickness (?CET) and postoperative Q-value changes (?Q) was analyzed 6 months
postoperatively. Results. Epithelial thickness at 6 months showed a negative
meniscus-like lenticular pattern with less central thickening, which increased
progressively toward the mid-periphery (3.69 ± 4.2, 5.19 ± 3.8, and 6.23 ± 3.9??m
at the center, paracenter, and mid-periphery, resp., P < 0.01). A significant
positive relationship was observed between epithelial thickening and ?Q 6 months
postoperatively (r = 0.438, 0.580, and 0.504, resp., P < 0.01). Conclusions.
Significant epithelial thickening was observed after T-PRK and showed a
lenticular change with more thickening mid-peripherally, resulting in increased
oblateness postoperatively. Epithelial remodeling may modify the epithelial
thickness profile after surface ablation refractive surgery for myopia.