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2016 ; 2016
(ä): 5902678
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The Significance of Long Noncoding RNA H19 in Predicting Progression and
Metastasis of Cancers: A Meta-Analysis
#MMPMID27672656
Jing W
; Zhu M
; Zhang XW
; Pan ZY
; Gao SS
; Zhou H
; Qiu SL
; Liang CZ
; Tu JC
Biomed Res Int
2016[]; 2016
(ä): 5902678
PMID27672656
show ga
Recently, numerous studies indicate that H19 plays a key role in tumorigenesis,
but the results have been disputed, especially in the aspects of tumor
progression and metastasis. Therefore, we performed this meta-analysis to
systematically summarize the relationship between H19 and cancers. We searched
PubMed, the Cochrane Library, CNKI, and Chinese Wan Fang to identify eligible
studies. Odds ratios and 95% confidence intervals were calculated to assess the
effect size. A total of 13 studies were enrolled in this meta-analysis, which was
performed by Revman5.3 and Stata11.0 software. Our meta-analysis showed that the
expression of H19 was associated with distant metastasis in nongastrointestinal
tumors (OR = 3.85, 95% CI = 1.31-11.36, P = 0.01) and, in gastrointestinal tumors
(OR = 0.34, 95% CI = 0.15-0.78, P = 0.01), lymph node metastasis (OR = 2.04, 95%
CI = 1.19-3.48, P = 0.009). Moreover, in gastric cancer, H19 expression was
significantly related to histological grade (OR = 0.50, 95% CI = 0.29-0.86, P =
0.01), TNM stage (OR = 0.19, 95% CI = 0.11-0.33, P < 0.01), and tumor invasion
depth (OR = 0.11, 95% CI = 0.04-0.27, P < 0.01). Therefore, H19 could serve as a
potential marker for progression and metastasis evaluation of cancers.