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10.1016/j.cmet.2016.06.020 http://scihub22266oqcxt.onion/10.1016/j.cmet.2016.06.020 C5031557!5031557!27452146     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Metab 2016 ; 24 (3): 389-401 Nephropedia Template TP {{tp|p=27452146|t=2016. Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose |pdf=|usr=}}{{27452146}} gab.com Text Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=27452146 #FOAvip The arrangement of ? cells within islets of Langerhans is critical for insulin release through the generation of rhythmic activity. A privileged role for individual ? cells in orchestrating these responses has long been suspected, but not directly demonstrated. We show here that the ? cell population in situ is operationally heterogeneous. Mapping of islet functional architecture revealed the presence of hub cells with pacemaker properties, which remain stable over recording periods of 2 to 3 hr. Using a dual optogenetic/photopharmacological strategy, silencing of hubs abolished coordinated islet responses to glucose, whereas specific stimulation restored communication patterns. Hubs were metabolically adapted and targeted by both pro-inflammatory and glucolipotoxic insults to induce widespread ? cell dysfunction. Thus, the islet is wired by hubs, whose failure may contribute to type 2 diabetes mellitus. Twit Text FOAVip Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=27452146 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27452146 #FOAvip English Wikipedia <ref>{{Cite pmid|27452146}}</ref> Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose #MMPMID27452146 Johnston N; Mitchell R; Haythorne E; Pessoa M; Semplici F; Ferrer J; Piemonti L; Marchetti P; Bugliani M; Bosco D; Berishvili E; Duncanson P; Watkinson M; Broichhagen J; Trauner D; Rutter G; Hodson D Cell Metab 2016[Sep]; 24 (3): 389-401 PMID27452146show ga The arrangement of ? cells within islets of Langerhans is critical for insulin release through the generation of rhythmic activity. A privileged role for individual ? cells in orchestrating these responses has long been suspected, but not directly demonstrated. We show here that the ? cell population in situ is operationally heterogeneous. Mapping of islet functional architecture revealed the presence of hub cells with pacemaker properties, which remain stable over recording periods of 2 to 3 hr. Using a dual optogenetic/photopharmacological strategy, silencing of hubs abolished coordinated islet responses to glucose, whereas specific stimulation restored communication patterns. Hubs were metabolically adapted and targeted by both pro-inflammatory and glucolipotoxic insults to induce widespread ? cell dysfunction. Thus, the islet is wired by hubs, whose failure may contribute to type 2 diabetes mellitus. äBeta Cell Hubs Dictate Pancreatic Islet Responses to Glucose (epmc).pdf DeepDyve Pubget Overpricing