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10.1084/jem.20160792 http://scihub22266oqcxt.onion/10.1084/jem.20160792 C5030811!5030811 !27621417     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27621417 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Exp+Med 2016 ; 213 (10 ): 1937-50 Nephropedia Template TP {{tp|p=27621417 |t=2016. Historical observations contributing insights on etiopathogenesis of rheumatoid arthritis and role of rheumatoid factor |pdf=|usr=}}{{27621417 }} gab.com Text Historical observations contributing insights on etiopathogenesis of rheumatoid arthritis and role of rheumatoid factor JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27621417 #FOAvip When studies on rheumatoid arthritis (RA) that were made many decades ago and could be considered "historical" in nature are analyzed in the context of recent observations, important insights on RA and on the function of rheumatoid factor (RF) become apparent. RF in the role of antibody to immune complexes (ICs) appears to be involved in activation of the complement system and in the production of chemotactic and inflammatory mediators, creating a condition that can be sustained and reinitiated. In the synovial cavity, a state of nonresolving inflammation is produced with the formation of citrullinated protein antigen-antibody complexes or other forms of ICs. This is followed by a second wave of IC production in the form of RF acting as antibody reactive with the initial ICs. Both of these processes are associated with complement consumption and production of inflammatory mediators. We present a model of an initiation phase of RA that might represent an example of repetitive formation of ICs and complement-mediated inflammation. Targeting therapy at this phase of RA to break the cycles of recurrent inflammation might be a novel approach to aid in further control of the disease. Twit Text FOAVip Historical observations contributing insights on etiopathogenesis of rheumatoid arthritis and role of rheumatoid factor ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27621417 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27621417 #FOAvip English Wikipedia <ref>{{Cite pmid|27621417 }}</ref> Historical observations contributing insights on etiopathogenesis of rheumatoid arthritis and role of rheumatoid factor #MMPMID27621417 Tan EM ; Smolen JS J Exp Med 2016[Sep]; 213 (10 ): 1937-50 PMID27621417 show ga When studies on rheumatoid arthritis (RA) that were made many decades ago and could be considered "historical" in nature are analyzed in the context of recent observations, important insights on RA and on the function of rheumatoid factor (RF) become apparent. RF in the role of antibody to immune complexes (ICs) appears to be involved in activation of the complement system and in the production of chemotactic and inflammatory mediators, creating a condition that can be sustained and reinitiated. In the synovial cavity, a state of nonresolving inflammation is produced with the formation of citrullinated protein antigen-antibody complexes or other forms of ICs. This is followed by a second wave of IC production in the form of RF acting as antibody reactive with the initial ICs. Both of these processes are associated with complement consumption and production of inflammatory mediators. We present a model of an initiation phase of RA that might represent an example of repetitive formation of ICs and complement-mediated inflammation. Targeting therapy at this phase of RA to break the cycles of recurrent inflammation might be a novel approach to aid in further control of the disease. |Animals [MESH] |Antibodies/metabolism [MESH] |Antigen-Antibody Complex/metabolism [MESH] |Arthritis, Rheumatoid/*etiology/therapy [MESH] |Humans [MESH] |Inflammation/immunology [MESH] |Models, Biological [MESH]Historical observations contributing insights on etiopathogenesis of r(epmc).pdf DeepDyve Pubget Overpricing