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10.1084/jem.20160248 http://scihub22266oqcxt.onion/10.1084/jem.20160248 C5030804!5030804 !27621419     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27621419 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Exp+Med 2016 ; 213 (10 ): 2065-80 Nephropedia Template TP {{tp|p=27621419 |t=2016. Epstein-Barr viral miRNAs inhibit antiviral CD4+ T cell responses targeting IL-12 and peptide processing |pdf=|usr=}}{{27621419 }} gab.com Text Epstein-Barr viral miRNAs inhibit antiviral CD4+ T cell responses targeting IL-12 and peptide processing JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27621419 #FOAvip Epstein-Barr virus (EBV) is a tumor virus that establishes lifelong infection in most of humanity, despite eliciting strong and stable virus-specific immune responses. EBV encodes at least 44 miRNAs, most of them with unknown function. Here, we show that multiple EBV miRNAs modulate immune recognition of recently infected primary B cells, EBV's natural target cells. EBV miRNAs collectively and specifically suppress release of proinflammatory cytokines such as IL-12, repress differentiation of naive CD4(+) T cells to Th1 cells, interfere with peptide processing and presentation on HLA class II, and thus reduce activation of cytotoxic EBV-specific CD4(+) effector T cells and killing of infected B cells. Our findings identify a previously unknown viral strategy of immune evasion. By rapidly expressing multiple miRNAs, which are themselves nonimmunogenic, EBV counteracts recognition by CD4(+) T cells and establishes a program of reduced immunogenicity in recently infected B cells, allowing the virus to express viral proteins required for establishment of life-long infection. Twit Text FOAVip Epstein-Barr viral miRNAs inhibit antiviral CD4+ T cell responses targeting IL-12 and peptide processing ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27621419 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27621419 #FOAvip English Wikipedia <ref>{{Cite pmid|27621419 }}</ref> Epstein-Barr viral miRNAs inhibit antiviral CD4+ T cell responses targeting IL-12 and peptide processing #MMPMID27621419 Tagawa T ; Albanese M ; Bouvet M ; Moosmann A ; Mautner J ; Heissmeyer V ; Zielinski C ; Lutter D ; Hoser J ; Hastreiter M ; Hayes M ; Sugden B ; Hammerschmidt W J Exp Med 2016[Sep]; 213 (10 ): 2065-80 PMID27621419 show ga Epstein-Barr virus (EBV) is a tumor virus that establishes lifelong infection in most of humanity, despite eliciting strong and stable virus-specific immune responses. EBV encodes at least 44 miRNAs, most of them with unknown function. Here, we show that multiple EBV miRNAs modulate immune recognition of recently infected primary B cells, EBV's natural target cells. EBV miRNAs collectively and specifically suppress release of proinflammatory cytokines such as IL-12, repress differentiation of naive CD4(+) T cells to Th1 cells, interfere with peptide processing and presentation on HLA class II, and thus reduce activation of cytotoxic EBV-specific CD4(+) effector T cells and killing of infected B cells. Our findings identify a previously unknown viral strategy of immune evasion. By rapidly expressing multiple miRNAs, which are themselves nonimmunogenic, EBV counteracts recognition by CD4(+) T cells and establishes a program of reduced immunogenicity in recently infected B cells, allowing the virus to express viral proteins required for establishment of life-long infection. |Antigen Presentation [MESH] |B-Lymphocytes/immunology/virology [MESH] |CD4-Positive T-Lymphocytes/*immunology [MESH] |Cell Death [MESH] |Cell Differentiation [MESH] |Cell Membrane/metabolism [MESH] |Cytokines/metabolism [MESH] |HEK293 Cells [MESH] |Herpesvirus 4, Human/*genetics [MESH] |Humans [MESH] |Immunity [MESH] |Inflammation Mediators/metabolism [MESH] |Interleukin-12/*metabolism [MESH] |Lysosomes/metabolism [MESH] |MicroRNAs/*genetics/metabolism [MESH] |Peptides/*metabolism [MESH] |Receptors, Cell Surface/metabolism [MESH] |Species Specificity [MESH]Epstein-Barr viral miRNAs inhibit antiviral CD4+ T cell responses targ(epmc).pdf DeepDyve Pubget Overpricing