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10.1084/jem.20150282 http://scihub22266oqcxt.onion/10.1084/jem.20150282 C5030794!5030794 !27621420     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27621420 &cmd=llinks): Failed to open stream: HTTP request failed! 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The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells |pdf=|usr=}}{{27621420 }} gab.com Text The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27621420 #FOAvip Pentraxin 3 (PTX3) is a fluid-phase pattern recognition receptor of the humoral innate immune system with ancestral antibody-like properties but unknown antibody-inducing function. In this study, we found binding of PTX3 to splenic marginal zone (MZ) B cells, an innate-like subset of antibody-producing lymphocytes strategically positioned at the interface between the circulation and the adaptive immune system. PTX3 was released by a subset of neutrophils that surrounded the splenic MZ and expressed an immune activation-related gene signature distinct from that of circulating neutrophils. Binding of PTX3 promoted homeostatic production of IgM and class-switched IgG antibodies to microbial capsular polysaccharides, which decreased in PTX3-deficient mice and humans. In addition, PTX3 increased IgM and IgG production after infection with blood-borne encapsulated bacteria or immunization with bacterial carbohydrates. This immunogenic effect stemmed from the activation of MZ B cells through a neutrophil-regulated pathway that elicited class switching and plasmablast expansion via a combination of T cell-independent and T cell-dependent signals. Thus, PTX3 may bridge the humoral arms of the innate and adaptive immune systems by serving as an endogenous adjuvant for MZ B cells. This property could be harnessed to develop more effective vaccines against encapsulated pathogens. Twit Text FOAVip The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27621420 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27621420 #FOAvip English Wikipedia <ref>{{Cite pmid|27621420 }}</ref> The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells #MMPMID27621420 Chorny A ; Casas-Recasens S ; Sintes J ; Shan M ; Polentarutti N ; García-Escudero R ; Walland AC ; Yeiser JR ; Cassis L ; Carrillo J ; Puga I ; Cunha C ; Bastos H ; Rodrigues F ; Lacerda JF ; Morais A ; Dieguez-Gonzalez R ; Heeger PS ; Salvatori G ; Carvalho A ; Garcia-Sastre A ; Blander JM ; Mantovani A ; Garlanda C ; Cerutti A J Exp Med 2016[Sep]; 213 (10 ): 2167-85 PMID27621420 show ga Pentraxin 3 (PTX3) is a fluid-phase pattern recognition receptor of the humoral innate immune system with ancestral antibody-like properties but unknown antibody-inducing function. In this study, we found binding of PTX3 to splenic marginal zone (MZ) B cells, an innate-like subset of antibody-producing lymphocytes strategically positioned at the interface between the circulation and the adaptive immune system. PTX3 was released by a subset of neutrophils that surrounded the splenic MZ and expressed an immune activation-related gene signature distinct from that of circulating neutrophils. Binding of PTX3 promoted homeostatic production of IgM and class-switched IgG antibodies to microbial capsular polysaccharides, which decreased in PTX3-deficient mice and humans. In addition, PTX3 increased IgM and IgG production after infection with blood-borne encapsulated bacteria or immunization with bacterial carbohydrates. This immunogenic effect stemmed from the activation of MZ B cells through a neutrophil-regulated pathway that elicited class switching and plasmablast expansion via a combination of T cell-independent and T cell-dependent signals. Thus, PTX3 may bridge the humoral arms of the innate and adaptive immune systems by serving as an endogenous adjuvant for MZ B cells. This property could be harnessed to develop more effective vaccines against encapsulated pathogens. |*Adaptive Immunity [MESH] |*Immunity, Humoral [MESH] |*Immunity, Innate [MESH] |Adult [MESH] |Animals [MESH] |Antibody Formation [MESH] |B-Lymphocytes/*metabolism [MESH] |Bacteria/metabolism [MESH] |Bacterial Capsules/metabolism [MESH] |C-Reactive Protein/*metabolism [MESH] |Cell Proliferation [MESH] |Female [MESH] |Gene Expression Profiling [MESH] |Humans [MESH] |Immunization [MESH] |Immunoglobulin Class Switching [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |NF-kappa B/metabolism [MESH] |Neutrophils/metabolism [MESH] |Plasma Cells/metabolism [MESH] |Protein Binding [MESH] |Receptors, IgG/metabolism [MESH] |Receptors, Pattern Recognition/*metabolism [MESH] |Recombination, Genetic/genetics [MESH] |Serum Amyloid P-Component/*metabolism [MESH] |Solubility [MESH] |Spleen/metabolism [MESH] |T-Lymphocytes/metabolism [MESH]The soluble pattern recognition receptor PTX3 links humoral innate and(epmc).pdf DeepDyve Pubget Overpricing