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10.1016/j.immuni.2015.11.011 http://scihub22266oqcxt.onion/10.1016/j.immuni.2015.11.011 C5030078!5030078!26777396     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2016 ; 44 (1): 73-87 Nephropedia Template TP {{tp|p=26777396|t=2016. The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation |pdf=|usr=}}{{26777396}} gab.com Text The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=26777396 #FOAvip Neutrophils are recruited from the blood to sites of sterile inflammation, where they are involved in wound healing but can also cause tissue damage. During sterile inflammation, necrotic cells release pro-inflammatory molecules including formylated peptides. However, the signaling pathway triggered by formylated peptides to integrin activation and leukocyte recruitment is unknown. By using spinning-disk confocal intravital microscopy, we examined the molecular mechanisms of leukocyte recruitment to sites of focal hepatic necrosis in vivo. We demonstrated that the Bruton?s tyrosine kinase (Btk) was required for multiple Mac-1 activation events involved in neutrophil recruitment and functions during sterile inflammation triggered by fMLF. The Src family kinase Hck, Wiskott-Aldrich-syndrome protein, and phospholipase C?2 were also involved in this pathway required for fMLF-triggered Mac-1 activation and neutrophil recruitment. Thus, we have identified a neutrophil Btk signalosome that is involved in a signaling pathway triggered by formylated peptides leading to the selective activation of Mac-1 and neutrophil recruitment during sterile inflammation. Twit Text FOAVip The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=26777396 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26777396 #FOAvip English Wikipedia <ref>{{Cite pmid|26777396}}</ref> The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation #MMPMID26777396 Volmering S; Block H; Boras M; Lowell CA; Zarbock A Immunity 2016[Jan]; 44 (1): 73-87 PMID26777396show ga Neutrophils are recruited from the blood to sites of sterile inflammation, where they are involved in wound healing but can also cause tissue damage. During sterile inflammation, necrotic cells release pro-inflammatory molecules including formylated peptides. However, the signaling pathway triggered by formylated peptides to integrin activation and leukocyte recruitment is unknown. By using spinning-disk confocal intravital microscopy, we examined the molecular mechanisms of leukocyte recruitment to sites of focal hepatic necrosis in vivo. We demonstrated that the Bruton?s tyrosine kinase (Btk) was required for multiple Mac-1 activation events involved in neutrophil recruitment and functions during sterile inflammation triggered by fMLF. The Src family kinase Hck, Wiskott-Aldrich-syndrome protein, and phospholipase C?2 were also involved in this pathway required for fMLF-triggered Mac-1 activation and neutrophil recruitment. Thus, we have identified a neutrophil Btk signalosome that is involved in a signaling pathway triggered by formylated peptides leading to the selective activation of Mac-1 and neutrophil recruitment during sterile inflammation. äThe Neutrophil Btk Signalosome Regulates Integrin Activation during St(epmc).pdf DeepDyve Pubget Overpricing