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10.18632/oncotarget.8293 http://scihub22266oqcxt.onion/10.18632/oncotarget.8293 C5029740!5029740!27015120     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (17): 24766-77 Nephropedia Template TP {{tp|p=27015120|t=2016. A comprehensive repertoire of tRNA-derived fragments in prostate cancer |pdf=|usr=}}{{27015120}} gab.com Text A comprehensive repertoire of tRNA-derived fragments in prostate cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27015120 #FOAvip Prostate cancer (PCa) is the most common cancer among men in developed countries. Although its genetic background is thoroughly investigated, rather little is known about the role of small non-coding RNAs (sncRNA) in this disease. tRNA-derived fragments (tRFs) represent a new class of sncRNAs, which are present in a broad range of species and have been reported to play a role in several cellular processes. Here, we analyzed the expression of tRFs in fresh frozen patient samples derived from normal adjacent prostate and different stages of PCa by RNA-sequencing. We identified 598 unique tRFs, many of which are deregulated in cancer samples when compared to normal adjacent tissue. Most of the identified tRFs are derived from the 5?- and 3?-ends of mature cytosolic tRNAs, but we also found tRFs produced from other parts of tRNAs, including pre-tRNA trailers and leaders, as well as tRFs from mitochondrial tRNAs. The 5?-derived tRFs comprise the most abundant class of tRFs in general and represent the major class among upregulated tRFs. The 3?-derived tRFs types are dominant among downregulated tRFs in PCa. We validated the expression of three tRFs using qPCR. The ratio of tRFs derived from tRNALysCTT and tRNAPheGAA emerged as a good indicator of progression-free survival and a candidate prognostic marker. This study provides a systematic catalogue of tRFs and their dysregulation in PCa and can serve as the basis for further research on the biomarker potential and functional roles of tRFs in this disease. Twit Text FOAVip A comprehensive repertoire of tRNA-derived fragments in prostate cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27015120 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27015120 #FOAvip English Wikipedia <ref>{{Cite pmid|27015120}}</ref> A comprehensive repertoire of tRNA-derived fragments in prostate cancer #MMPMID27015120 Olvedy M; Scaravilli M; Hoogstrate Y; Visakorpi T; Jenster G; Martens ES Oncotarget 2016[Apr]; 7 (17): 24766-77 PMID27015120show ga Prostate cancer (PCa) is the most common cancer among men in developed countries. Although its genetic background is thoroughly investigated, rather little is known about the role of small non-coding RNAs (sncRNA) in this disease. tRNA-derived fragments (tRFs) represent a new class of sncRNAs, which are present in a broad range of species and have been reported to play a role in several cellular processes. Here, we analyzed the expression of tRFs in fresh frozen patient samples derived from normal adjacent prostate and different stages of PCa by RNA-sequencing. We identified 598 unique tRFs, many of which are deregulated in cancer samples when compared to normal adjacent tissue. Most of the identified tRFs are derived from the 5?- and 3?-ends of mature cytosolic tRNAs, but we also found tRFs produced from other parts of tRNAs, including pre-tRNA trailers and leaders, as well as tRFs from mitochondrial tRNAs. The 5?-derived tRFs comprise the most abundant class of tRFs in general and represent the major class among upregulated tRFs. The 3?-derived tRFs types are dominant among downregulated tRFs in PCa. We validated the expression of three tRFs using qPCR. The ratio of tRFs derived from tRNALysCTT and tRNAPheGAA emerged as a good indicator of progression-free survival and a candidate prognostic marker. This study provides a systematic catalogue of tRFs and their dysregulation in PCa and can serve as the basis for further research on the biomarker potential and functional roles of tRFs in this disease. äA comprehensive repertoire of tRNA-derived fragments in prostate cance(epmc).pdf DeepDyve Pubget Overpricing