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2016 ; 7
(17
): 24623-32
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Proper hepatic pedicle clamping during hepatectomy is associated with improved
postoperative long-term prognosis in patients with AJCC stage IIIB hepatocellular
carcinoma
#MMPMID27027437
Li X
; Liu S
; Li H
; Guo L
; Zhang B
; Lin Z
; Zhang J
; Ye Q
Oncotarget
2016[Apr]; 7
(17
): 24623-32
PMID27027437
show ga
Intermittent hepatic pedicle clamping (HPC) is often performed during
hepatectomy. Whether it affects the long-term prognosis of hepatocellular
carcinoma (HCC) patients is still controversial. This study evaluated the impact
of HPC in patients with different stages of HCC. The study included 1401 patients
who underwent hepatectomy in the primary cohort with 129 AJCC stage IIIB HCC
patients; there were 80 AJCC stage IIIB HCC patients in the validation cohort. In
each cohort, patients were placed in the long-term HPC (LTHPC) group or the
short-term HPC (STHPC) group based on the cut-off time of HPC estimated by the
receiver-operating characteristic (ROC) curve. Although HPC did not show
significant effects on the prognosis of stage I-IIIA HCC patients in the primary
cohort, 1-, 3-, and 5-year overall survival (OS) and recurrence-free survival
(RFS) rates of stage IIIB HCC patients who received LTHPC (HPC time > 12 minutes)
were significantly higher than those with STHPC (HPC time ? 12 minutes or
received no HPC), similar in the validation cohort. Multivariate analysis
demonstrated HPC time was an independent protective factor for RFS and OS in
stage IIIB HCC patients. Herein, we report that proper HPC improved the
postoperative prognosis of stage IIIB HCC patients and served as an independent
protective factor.