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10.18632/oncotarget.8081 http://scihub22266oqcxt.onion/10.18632/oncotarget.8081 C5029674!5029674!26993595     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (17): 23919-32 Nephropedia Template TP {{tp|p=26993595|t=2016. Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth |pdf=|usr=}}{{26993595}} gab.com Text Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26993595 #FOAvip We hypothesized that tumor-associated macrophages (TAMs) are controlled by the diffusible gas carbon monoxide (CO). We demonstrate that induction of apoptosis in lung tumors treated with low doses of CO is associated with increased CD86 expression and activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinases (Erk) 1/2 pathway in tumor microenvironment. Presence of CD86-positive cells was required for the anti-tumoral effects of CO in established A549 xenografts. We show that the effects of CO on tumor stroma and reprogramming of macrophages towards the anti-tumoral phenotype is mediated by reactive oxygen species (ROS)-dependent activation of MAPK/Erk1/2-c-myc pathway as well as Notch 1-dependent negative feedback on the metabolic enzyme heme oxygenase-1 (HO-1). We find a similar negative correlation between HO-1 and active MAPK-Erk1/2 levels in human lung cancer specimens.In summary, we describe novel non-cell autonomous mechanisms by which the diffusible gas CO dictates changes in the tumor microenvironment through the modulation of macrophages. Twit Text FOAVip Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26993595 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26993595 #FOAvip English Wikipedia <ref>{{Cite pmid|26993595}}</ref> Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth #MMPMID26993595 Nemeth Z; Csizmadia E; Vikstrom L; Li M; Bisht K; Feizi A; Otterbein S; Zuckerbraun B; Costa DB; Pandolfi PP; Fillinger J; Döme B; Otterbein LE; Wegiel B Oncotarget 2016[Apr]; 7 (17): 23919-32 PMID26993595show ga We hypothesized that tumor-associated macrophages (TAMs) are controlled by the diffusible gas carbon monoxide (CO). We demonstrate that induction of apoptosis in lung tumors treated with low doses of CO is associated with increased CD86 expression and activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinases (Erk) 1/2 pathway in tumor microenvironment. Presence of CD86-positive cells was required for the anti-tumoral effects of CO in established A549 xenografts. We show that the effects of CO on tumor stroma and reprogramming of macrophages towards the anti-tumoral phenotype is mediated by reactive oxygen species (ROS)-dependent activation of MAPK/Erk1/2-c-myc pathway as well as Notch 1-dependent negative feedback on the metabolic enzyme heme oxygenase-1 (HO-1). We find a similar negative correlation between HO-1 and active MAPK-Erk1/2 levels in human lung cancer specimens.In summary, we describe novel non-cell autonomous mechanisms by which the diffusible gas CO dictates changes in the tumor microenvironment through the modulation of macrophages. äAlterations of tumor microenvironment by carbon monoxide impedes lung (epmc).pdf DeepDyve Pubget Overpricing