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10.18632/oncotarget.8179 http://scihub22266oqcxt.onion/10.18632/oncotarget.8179 C5029659!5029659!27009861     free     free     free       Oncotarget 2016 ; 7 (17): 23730-9 Nephropedia Template TP {{tp|p=27009861|t=2016. Dormancy activation mechanism of tracheal stem cells |pdf=|usr=}}{{27009861}} gab.com Text Dormancy activation mechanism of tracheal stem cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27009861 #FOAvip Accurate markers and molecular mechanisms of stem cell dormancy and activation are poorly understood. In this study, the anti-cancer drug, 5-fluorouracil, was used to selectively kill proliferating cells of human bronchial epithelial (HBE) cell line. This method can enrich and purify stem cell population. The dormant versus active status of stem cells was determined by phosphorylation of RNAp II Ser2. The surviving stem cells were cultured to form stem cell spheres expressing stem cell markers and transplanted into nude mice to form a teratoma. The results demonstrated the properties of stem cells and potential for multi-directional differentiation. Bisulfite sequencing polymerase chain reaction showed that demethylation of the Sox2 promoter by 5-FU resulted in Sox2 expression in the dormant stem cells. This study shows that the dormancy and activation of HBE stem cells is closely related to epigenetic modification. Twit Text FOAVip Dormancy activation mechanism of tracheal stem cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27009861 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27009861 #FOAvip English Wikipedia <ref>{{Cite pmid|27009861}}</ref> Dormancy activation mechanism of tracheal stem cells #MMPMID27009861 Li X; Xu Jx; Jia XS; Li Wy; Han Yc; Wang Eh; Li F Oncotarget 2016[Apr]; 7 (17): 23730-9 PMID27009861show ga Accurate markers and molecular mechanisms of stem cell dormancy and activation are poorly understood. In this study, the anti-cancer drug, 5-fluorouracil, was used to selectively kill proliferating cells of human bronchial epithelial (HBE) cell line. This method can enrich and purify stem cell population. The dormant versus active status of stem cells was determined by phosphorylation of RNAp II Ser2. The surviving stem cells were cultured to form stem cell spheres expressing stem cell markers and transplanted into nude mice to form a teratoma. The results demonstrated the properties of stem cells and potential for multi-directional differentiation. Bisulfite sequencing polymerase chain reaction showed that demethylation of the Sox2 promoter by 5-FU resulted in Sox2 expression in the dormant stem cells. This study shows that the dormancy and activation of HBE stem cells is closely related to epigenetic modification. äDormancy activation mechanism of tracheal stem cells (epmc).pdf DeepDyve Pubget Overpricing