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10.18632/oncotarget.8152 http://scihub22266oqcxt.onion/10.18632/oncotarget.8152 C5029656!5029656 !27008697     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27008697 &cmd=llinks): Failed to open stream: HTTP request failed! 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Escin Ia suppresses the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expression |pdf=|usr=}}{{27008697 }} gab.com Text Escin Ia suppresses the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expression JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27008697 #FOAvip The saponin fraction of Aesculus chinensis Bunge fruits (SFAC) could inhibit the invasion and migration of MDA-MB-231 cells. Among which, escin Ia showed more potent inhibition of the invasion than other five main saponin constituents. It selectively reduced the expression of LOXL2 mRNA and promoted the expression of E-cadherin mRNA, and prevented the EMT process of MDA-MB-231 cells and TNF-?/TGF-?-stimulated MCF-7 cells. Moreover, it reduced the LOXL2 level in MDA-MB-231 cells but not in MCF-7 cells. When MCF-7 cells were stimulated with TNF-?/TGF-?, transfected with LOXL2 or treated with hypoxia, escin Ia down-regulated the level of LOXL2 in MCF-7 cells. Meanwhile, escin Ia suppressed the EMT process in LOXL2-transfected or hypoxia-treated MCF-7 cells. Of interest, escin Ia did not alter the level of HIF-1? in hypoxia-induced MCF-7 cells. In TNBC xenograft mice, the metastasis and EMT of MDA-MB-231 cells were suppressed by escin Ia. In conclusion, escin Ia was the main active ingredient of SFAC for the anti-TNBC metastasis activity, and its action mechanisms involved inhibition of EMT process by down-regulating LOXL2 expression. Twit Text FOAVip Escin Ia suppresses the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expression ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27008697 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27008697 #FOAvip English Wikipedia <ref>{{Cite pmid|27008697 }}</ref> Escin Ia suppresses the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expression #MMPMID27008697 Wang Y ; Xu X ; Zhao P ; Tong B ; Wei Z ; Dai Y Oncotarget 2016[Apr]; 7 (17 ): 23684-99 PMID27008697 show ga The saponin fraction of Aesculus chinensis Bunge fruits (SFAC) could inhibit the invasion and migration of MDA-MB-231 cells. Among which, escin Ia showed more potent inhibition of the invasion than other five main saponin constituents. It selectively reduced the expression of LOXL2 mRNA and promoted the expression of E-cadherin mRNA, and prevented the EMT process of MDA-MB-231 cells and TNF-?/TGF-?-stimulated MCF-7 cells. Moreover, it reduced the LOXL2 level in MDA-MB-231 cells but not in MCF-7 cells. When MCF-7 cells were stimulated with TNF-?/TGF-?, transfected with LOXL2 or treated with hypoxia, escin Ia down-regulated the level of LOXL2 in MCF-7 cells. Meanwhile, escin Ia suppressed the EMT process in LOXL2-transfected or hypoxia-treated MCF-7 cells. Of interest, escin Ia did not alter the level of HIF-1? in hypoxia-induced MCF-7 cells. In TNBC xenograft mice, the metastasis and EMT of MDA-MB-231 cells were suppressed by escin Ia. In conclusion, escin Ia was the main active ingredient of SFAC for the anti-TNBC metastasis activity, and its action mechanisms involved inhibition of EMT process by down-regulating LOXL2 expression. |Amino Acid Oxidoreductases/*antagonists & inhibitors/genetics/metabolism [MESH] |Animals [MESH] |Apoptosis/drug effects [MESH] |Biomarkers, Tumor/genetics/metabolism [MESH] |Cell Proliferation/drug effects [MESH] |Epithelial-Mesenchymal Transition/*drug effects [MESH] |Escin/*pharmacology [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic/*drug effects [MESH] |Humans [MESH] |Lymphatic Metastasis [MESH] |Mice [MESH] |Mice, Nude [MESH] |Neoplasm Invasiveness [MESH] |Triple Negative Breast Neoplasms/metabolism/*prevention & control/secondary [MESH] |Tumor Cells, Cultured [MESH]Escin Ia suppresses the metastasis of triple-negative breast cancer by(epmc).pdf DeepDyve Pubget Overpricing