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10.18632/oncotarget.8111 http://scihub22266oqcxt.onion/10.18632/oncotarget.8111 C5029637!5029637 !26993600     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26993600 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (17 ): 23425-38 Nephropedia Template TP {{tp|p=26993600 |t=2016. Tumor growth suppressive effect of IL-4 through p21-mediated activation of STAT6 in IL-4R? overexpressed melanoma models |pdf=|usr=}}{{26993600 }} gab.com Text Tumor growth suppressive effect of IL-4 through p21-mediated activation of STAT6 in IL-4R overexpressed melanoma models JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26993600 #FOAvip To evaluate the significance of interleukin 4 (IL-4) in tumor development, we compared B16F10 melanoma growth in IL-4-overespressing transgenic mice (IL-4 mice) and non-transgenic mice. In IL-4 mice, reduced tumor volume and weight were observed when compared with those of non-transgenic mice. Significant activation of DNA binding activity of STAT6, phosphorylation of STAT6 as well as IL-4, IL-4R? and p21 expression were found in the tumor tissues of IL-4 mice compared to non-transgenic mice. Higher expression of IL-4, STAT6 and p21 in human melanoma tissue compared to normal human skin tissue was also found. Higher expression of apoptotic protein such as cleaved caspase-3, cleaved caspase-8, cleaved caspase-9, Bax, p53 and p21, but lower expression levels of survival protein such as Bcl-2 were found in the tumor of IL-4 mice. In vitro study, we found that overexpression of IL-4 significantly inhibited SK-MEL-28 human melanoma cell and B16F10 murine melanoma cell growth via p21-mediated activation of STAT6 pathway as well as increased expression of apoptotic cell death proteins. Moreover, p21 knockdown with siRNA abolished IL-4 induced activation of STAT6 and expression of p53 and p21 accompanied with reduced IL-4 expression as well as melanoma cell growth inhibition. Therefore, these results showed that IL-4 overexpression suppressed tumor development through p21-mediated activation of STAT6 pathways in melanoma models. Twit Text FOAVip Tumor growth suppressive effect of IL-4 through p21-mediated activation of STAT6 in IL-4R overexpressed melanoma models ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26993600 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26993600 #FOAvip English Wikipedia <ref>{{Cite pmid|26993600 }}</ref> Tumor growth suppressive effect of IL-4 through p21-mediated activation of STAT6 in IL-4R? overexpressed melanoma models #MMPMID26993600 Lee HL ; Park MH ; Song JK ; Jung YY ; Kim Y ; Kim KB ; Hwang DY ; Yoon do Y ; Song MJ ; Han SB ; Hong JT Oncotarget 2016[Apr]; 7 (17 ): 23425-38 PMID26993600 show ga To evaluate the significance of interleukin 4 (IL-4) in tumor development, we compared B16F10 melanoma growth in IL-4-overespressing transgenic mice (IL-4 mice) and non-transgenic mice. In IL-4 mice, reduced tumor volume and weight were observed when compared with those of non-transgenic mice. Significant activation of DNA binding activity of STAT6, phosphorylation of STAT6 as well as IL-4, IL-4R? and p21 expression were found in the tumor tissues of IL-4 mice compared to non-transgenic mice. Higher expression of IL-4, STAT6 and p21 in human melanoma tissue compared to normal human skin tissue was also found. Higher expression of apoptotic protein such as cleaved caspase-3, cleaved caspase-8, cleaved caspase-9, Bax, p53 and p21, but lower expression levels of survival protein such as Bcl-2 were found in the tumor of IL-4 mice. In vitro study, we found that overexpression of IL-4 significantly inhibited SK-MEL-28 human melanoma cell and B16F10 murine melanoma cell growth via p21-mediated activation of STAT6 pathway as well as increased expression of apoptotic cell death proteins. Moreover, p21 knockdown with siRNA abolished IL-4 induced activation of STAT6 and expression of p53 and p21 accompanied with reduced IL-4 expression as well as melanoma cell growth inhibition. Therefore, these results showed that IL-4 overexpression suppressed tumor development through p21-mediated activation of STAT6 pathways in melanoma models. |Animals [MESH] |Apoptosis [MESH] |Biomarkers, Tumor/genetics/*metabolism [MESH] |Cell Proliferation [MESH] |Cyclin-Dependent Kinase Inhibitor p21/genetics/*metabolism [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Humans [MESH] |Interleukin-4 Receptor alpha Subunit/genetics/*metabolism [MESH] |Interleukin-4/genetics/*metabolism [MESH] |Male [MESH] |Melanoma/genetics/metabolism/*pathology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Inbred DBA [MESH] |Mice, Transgenic [MESH] |Prognosis [MESH] |STAT6 Transcription Factor/genetics/*metabolism [MESH] |Tumor Cells, Cultured [MESH]Tumor growth suppressive effect of IL-4 through p21-mediated activatio(epmc).pdf DeepDyve Pubget Overpricing