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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Stem+Cell+Res+Ther 2016 ; 7 (ä): ä Nephropedia Template TP
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The mechanosensor of mesenchymal stem cells: mechanosensitive channel or cytoskeleton? #MMPMID27651019
Xiao E; Chen C; Zhang Y
Stem Cell Res Ther 2016[]; 7 (ä): ä PMID27651019show ga
Mesenchymal stem cells (MSCs) are multipotent adult stem cells. MSCs and their potential for use in regenerative medicine have been investigated extensively. Recently, the mechanisms by which MSCs detect mechanical stimuli have been described in detail. As in other cell types, both mechanosensitive channels, such as transient receptor potential melastatin 7 (TRPM7), and the cytoskeleton, including actin and actomyosin, have been implicated in mechanosensation in MSCs. This review will focus on discussing the precise role of TRPM7 and the cytoskeleton in mechanosensation in MSCs.