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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cancer+Res 2016 ; 76 (18): 5189-91 Nephropedia Template TP
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p21(WAF1) mediates cell cycle inhibition, relevant to cancer suppression and therapy #MMPMID27635040
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Cancer Res 2016[Sep]; 76 (18): 5189-91 PMID27635040show ga
p21 (WAF1/CIP1; CDKN1a) is a universal cell cycle inhibitor directly controlled by p53 and p53-independent pathways. Knowledge of the regulation and function of p21 in normal and cancer cells has opened up several areas of investigation and has led to novel therapeutic strategies. The discovery in 1993 and subsequent work on p21 has illuminated basic cellular growth control, stem cell phenotypes, the physiology of differentiation, as well as how cells respond to stress. There remain open questions in the signaling networks, the ultimate role of p21 in the p53-deficiency phenotype in the context of other p53 target defects, and therapeutic strategies continue to be a work-in-progress.