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10.1371/journal.pone.0162296 http://scihub22266oqcxt.onion/10.1371/journal.pone.0162296 C5028023!5028023 !27643879     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27643879 &cmd=llinks): Failed to open stream: HTTP request failed! 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Evaluation of 10 AMD Associated Polymorphisms as a Cause of Choroidal Neovascularization in Highly Myopic Eyes |pdf=|usr=}}{{27643879 }} gab.com Text Evaluation of 10 AMD Associated Polymorphisms as a Cause of Choroidal Neovascularization in Highly Myopic Eyes JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27643879 #FOAvip Choroidal neovascularization (CNV) commonly occurs in age related macular degeneration and pathological myopia patients. In this study we conducted a case-control prospective study including 431 participants. The aim of this study was to determine the potential association between 10 single nucleotide polymorphisms (SNPs) located in 4 different genetic regions (CFI, COL8A1, LIPC, and APOE), and choroidal neovascularization in age-related macular degeneration and the development of choroidal neovascularization in highly myopic eyes of a Caucasian population. Univariate and multivariate logistic regression analysis adjusted for age, sex and hypertension was performed for each allele, genotype and haplotype frequency analysis. We found that in the univariate analysis that both single-nucleotide polymorphisms in COL8A1 gene (rs13095226 and rs669676) together with age, sex and hypertension were significantly associated with myopic CNV development in Spanish patients (p<0.05). After correcting for multiple testing none of the polymorphisms studied remained significantly associated with myopic CNV (p>0.05); however, analysis of the axial length between genotypes of rs13095226 revealed an important influence of COL8A1 in the development of CNV in high myopia. Furthermore we conducted a meta-analysis of COL8A1, CFI and LIPC genes SNPs (rs669676, rs10033900 and rs10468017) and found that only rs669676 of these SNPs were associated with high myopia neovascularization. Twit Text FOAVip Evaluation of 10 AMD Associated Polymorphisms as a Cause of Choroidal Neovascularization in Highly Myopic Eyes ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27643879 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27643879 #FOAvip English Wikipedia <ref>{{Cite pmid|27643879 }}</ref> Evaluation of 10 AMD Associated Polymorphisms as a Cause of Choroidal Neovascularization in Highly Myopic Eyes #MMPMID27643879 Velazquez-Villoria A ; Recalde S ; Anter J ; Bezunartea J ; Hernandez-Sanchez M ; García-García L ; Alonso E ; Ruiz-Moreno JM ; Araiz-Iribarren J ; Fernandez-Robredo P ; García-Layana A PLoS One 2016[]; 11 (9 ): e0162296 PMID27643879 show ga Choroidal neovascularization (CNV) commonly occurs in age related macular degeneration and pathological myopia patients. In this study we conducted a case-control prospective study including 431 participants. The aim of this study was to determine the potential association between 10 single nucleotide polymorphisms (SNPs) located in 4 different genetic regions (CFI, COL8A1, LIPC, and APOE), and choroidal neovascularization in age-related macular degeneration and the development of choroidal neovascularization in highly myopic eyes of a Caucasian population. Univariate and multivariate logistic regression analysis adjusted for age, sex and hypertension was performed for each allele, genotype and haplotype frequency analysis. We found that in the univariate analysis that both single-nucleotide polymorphisms in COL8A1 gene (rs13095226 and rs669676) together with age, sex and hypertension were significantly associated with myopic CNV development in Spanish patients (p<0.05). After correcting for multiple testing none of the polymorphisms studied remained significantly associated with myopic CNV (p>0.05); however, analysis of the axial length between genotypes of rs13095226 revealed an important influence of COL8A1 in the development of CNV in high myopia. Furthermore we conducted a meta-analysis of COL8A1, CFI and LIPC genes SNPs (rs669676, rs10033900 and rs10468017) and found that only rs669676 of these SNPs were associated with high myopia neovascularization. |*Polymorphism, Single Nucleotide [MESH] |Aged [MESH] |Apolipoproteins E/genetics [MESH] |Choroid/blood supply/pathology [MESH] |Choroidal Neovascularization/complications/*genetics/pathology [MESH] |Collagen Type VIII/genetics [MESH] |Complement Factor I/genetics [MESH] |Female [MESH] |Humans [MESH] |Lipase/genetics [MESH] |Macular Degeneration/complications/*genetics/pathology [MESH] |Male [MESH] |Middle Aged [MESH] |Myopia, Degenerative/complications/*genetics/pathology [MESH]Evaluation of 10 AMD Associated Polymorphisms as a Cause of Choroidal (epmc).pdf DeepDyve Pubget Overpricing