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10.1097/MPG.0000000000000678 http://scihub22266oqcxt.onion/10.1097/MPG.0000000000000678 C5027895!5027895!25539191     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25539191&cmd=llinks): Failed to open stream: HTTP request failed! 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Oral Administration of Surfactant Protein-A Reduces Pathology in an Experimental Model of Necrotizing Enterocolitis |pdf=|usr=}}{{25539191}} gab.com Text Oral Administration of Surfactant Protein-A Reduces Pathology in an Experimental Model of Necrotizing Enterocolitis JO: J Pediatr Gastroenterol Nutr http://www.kidney.de/pget.php?&tw=1&pmid=25539191 #FOAvip OBJECTIVES: Necrotizing enterocolitis (NEC) frequently results in significant morbidity and mortality in premature infants. Others reported that mice deficient in pulmonary surfactant protein-A (SP-A) born and raised in a nonhygienic environment succumb to significant gastrointestinal tract pathology, and enteral administration of purified SP-A significantly reduced mortality. We hypothesized that oral administration of purified SP-A can ameliorate pathology in an experimental model of neonatal NEC. METHODS: Experimental NEC was induced in newborn Sprague-Dawley rat pups by daily formula gavage and intermittent exposure to hypoxia. Purified human SP-A (5 ?g/day) was administered by oral gavage. After 4 days, surviving pups were sacrificed, and intestinal pathology was assessed by histological examination of distal terminal ileal sections. Intestinal levels of inflammatory cytokines (IL-1?, IFN-? and TNF-?) were assessed by ELISA and levels of toll-like receptor 4 (TLR4) by western analysis. RESULTS: 61% of the gavaged rat pups that survived to day 4 met the criteria for experimental NEC after hypoxia while treatment with SP-A significantly reduced mortality and assessment of NEC. Intestinal levels of pro-inflammatory cytokines were significantly increased in pups exposed to hypoxia. Administration of SP-A to pups exposed to hypoxia significantly reduced IL-1? and TNF-? levels, but had little effect on elevated levels of IFN-?. SP-A treatment of hypoxia-exposed pups significantly reduced expression of intestinal TLR4, key in NEC pathogenesis. CONCLUSIONS: In a rat model of experimental neonatal NEC, oral administration of SP-A reduces intestinal levels of pro-inflammatory cytokines and TLR4 protein, and ameliorates adverse outcomes associated with gastrointestinal pathologies. Twit Text FOAVip Oral Administration of Surfactant Protein-A Reduces Pathology in an Experimental Model of Necrotizing Enterocolitis ????J Pediatr Gastroenterol Nutr http://www.kidney.de/pget.php?&tw=1&pmid=25539191 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25539191 #FOAvip English Wikipedia <ref>{{Cite pmid|25539191}}</ref> Oral Administration of Surfactant Protein-A Reduces Pathology in an Experimental Model of Necrotizing Enterocolitis #MMPMID25539191 Quintanilla HD; Liu Y; Fatheree NY; Atkins CL; Hashmi SS; Floros J; McCormack FX; Rhoads JM; Alcorn JL J Pediatr Gastroenterol Nutr 2015[May]; 60 (5): 613-20 PMID25539191show ga OBJECTIVES: Necrotizing enterocolitis (NEC) frequently results in significant morbidity and mortality in premature infants. Others reported that mice deficient in pulmonary surfactant protein-A (SP-A) born and raised in a nonhygienic environment succumb to significant gastrointestinal tract pathology, and enteral administration of purified SP-A significantly reduced mortality. We hypothesized that oral administration of purified SP-A can ameliorate pathology in an experimental model of neonatal NEC. METHODS: Experimental NEC was induced in newborn Sprague-Dawley rat pups by daily formula gavage and intermittent exposure to hypoxia. Purified human SP-A (5 ?g/day) was administered by oral gavage. After 4 days, surviving pups were sacrificed, and intestinal pathology was assessed by histological examination of distal terminal ileal sections. Intestinal levels of inflammatory cytokines (IL-1?, IFN-? and TNF-?) were assessed by ELISA and levels of toll-like receptor 4 (TLR4) by western analysis. RESULTS: 61% of the gavaged rat pups that survived to day 4 met the criteria for experimental NEC after hypoxia while treatment with SP-A significantly reduced mortality and assessment of NEC. Intestinal levels of pro-inflammatory cytokines were significantly increased in pups exposed to hypoxia. Administration of SP-A to pups exposed to hypoxia significantly reduced IL-1? and TNF-? levels, but had little effect on elevated levels of IFN-?. SP-A treatment of hypoxia-exposed pups significantly reduced expression of intestinal TLR4, key in NEC pathogenesis. CONCLUSIONS: In a rat model of experimental neonatal NEC, oral administration of SP-A reduces intestinal levels of pro-inflammatory cytokines and TLR4 protein, and ameliorates adverse outcomes associated with gastrointestinal pathologies. äOral Administration of Surfactant Protein-A Reduces Pathology in an Ex(epmc).pdf DeepDyve Pubget Overpricing