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10.1097/MPG.0000000000000678 http://scihub22266oqcxt.onion/10.1097/MPG.0000000000000678 C5027895!5027895 !25539191     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25539191 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Pediatr+Gastroenterol+Nutr 2015 ; 60 (5 ): 613-20 Nephropedia Template TP {{tp|p=25539191 |t=2015. Oral administration of surfactant protein-a reduces pathology in an experimental model of necrotizing enterocolitis |pdf=|usr=}}{{25539191 }} gab.com Text Oral administration of surfactant protein-a reduces pathology in an experimental model of necrotizing enterocolitis JO: J Pediatr Gastroenterol Nutr http://www.kidney.de/pget.php?&tw=1&pmid=25539191 #FOAvip OBJECTIVES: Necrotizing enterocolitis (NEC) frequently results in significant morbidity and mortality in premature infants. Others reported that mice deficient in pulmonary surfactant protein-A (SP-A) born and raised in a nonhygienic environment succumb to significant gastrointestinal tract pathology, and enteral administration of purified SP-A significantly reduced mortality. We hypothesized that oral administration of purified SP-A can ameliorate pathology in an experimental model of neonatal NEC. METHODS: Experimental NEC was induced in newborn Sprague-Dawley rat pups by daily formula gavage and intermittent exposure to hypoxia. Purified human SP-A (5 ?g/day) was administered by oral gavage. After 4 days, surviving pups were sacrificed, and intestinal pathology was assessed by histological examination of distal terminal ileal sections. Intestinal levels of inflammatory cytokines (IL-1?, IFN-?, and TNF-?) were assessed by enzyme-linked immunosorbent assay and levels of Toll-like receptor 4 (TLR4) by Western analysis. RESULTS: Sixty-one percent of the gavaged rat pups that survived to day 4 met the criteria for experimental NEC after hypoxia, whereas treatment with SP-A significantly reduced mortality and assessment of NEC. Intestinal levels of proinflammatory cytokines were significantly increased in pups exposed to hypoxia. Administration of SP-A to pups exposed to hypoxia significantly reduced IL-1? and TNF-? levels, but had little effect on elevated levels of IFN-?. SP-A treatment of hypoxia-exposed pups significantly reduced expression of intestinal TLR4, key in NEC pathogenesis. CONCLUSIONS: In a rat model of experimental neonatal NEC, oral administration of SP-A reduces intestinal levels of proinflammatory cytokines and TLR4 protein and ameliorates adverse outcomes associated with gastrointestinal pathologies. Twit Text FOAVip Oral administration of surfactant protein-a reduces pathology in an experimental model of necrotizing enterocolitis ????J Pediatr Gastroenterol Nutr http://www.kidney.de/pget.php?&tw=1&pmid=25539191 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25539191 #FOAvip English Wikipedia <ref>{{Cite pmid|25539191 }}</ref> Oral administration of surfactant protein-a reduces pathology in an experimental model of necrotizing enterocolitis #MMPMID25539191 Quintanilla HD ; Liu Y ; Fatheree NY ; Atkins CL ; Hashmi SS ; Floros J ; McCormack FX ; Rhoads JM ; Alcorn JL J Pediatr Gastroenterol Nutr 2015[May]; 60 (5 ): 613-20 PMID25539191 show ga OBJECTIVES: Necrotizing enterocolitis (NEC) frequently results in significant morbidity and mortality in premature infants. Others reported that mice deficient in pulmonary surfactant protein-A (SP-A) born and raised in a nonhygienic environment succumb to significant gastrointestinal tract pathology, and enteral administration of purified SP-A significantly reduced mortality. We hypothesized that oral administration of purified SP-A can ameliorate pathology in an experimental model of neonatal NEC. METHODS: Experimental NEC was induced in newborn Sprague-Dawley rat pups by daily formula gavage and intermittent exposure to hypoxia. Purified human SP-A (5 ?g/day) was administered by oral gavage. After 4 days, surviving pups were sacrificed, and intestinal pathology was assessed by histological examination of distal terminal ileal sections. Intestinal levels of inflammatory cytokines (IL-1?, IFN-?, and TNF-?) were assessed by enzyme-linked immunosorbent assay and levels of Toll-like receptor 4 (TLR4) by Western analysis. RESULTS: Sixty-one percent of the gavaged rat pups that survived to day 4 met the criteria for experimental NEC after hypoxia, whereas treatment with SP-A significantly reduced mortality and assessment of NEC. Intestinal levels of proinflammatory cytokines were significantly increased in pups exposed to hypoxia. Administration of SP-A to pups exposed to hypoxia significantly reduced IL-1? and TNF-? levels, but had little effect on elevated levels of IFN-?. SP-A treatment of hypoxia-exposed pups significantly reduced expression of intestinal TLR4, key in NEC pathogenesis. CONCLUSIONS: In a rat model of experimental neonatal NEC, oral administration of SP-A reduces intestinal levels of proinflammatory cytokines and TLR4 protein and ameliorates adverse outcomes associated with gastrointestinal pathologies. |Administration, Oral [MESH] |Animals [MESH] |Cytokines/*metabolism [MESH] |Disease Models, Animal [MESH] |Enterocolitis, Necrotizing/*drug therapy/metabolism/pathology [MESH] |Ileum/metabolism [MESH] |Interferon-gamma/metabolism [MESH] |Interleukin-1beta/metabolism [MESH] |Pulmonary Surfactant-Associated Protein A/*administration & dosage [MESH] |Pulmonary Surfactants/*administration & dosage [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH] |Toll-Like Receptor 4/metabolism [MESH]Oral administration of surfactant protein-a reduces pathology in an ex(epmc).pdf DeepDyve Pubget Overpricing