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10.1212/WNL.0000000000003088 http://scihub22266oqcxt.onion/10.1212/WNL.0000000000003088 C5027806!5027806!27534713     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neurology 2016 ; 87 (11): 1110-7 Nephropedia Template TP {{tp|p=27534713|t=2016. Cortical superficial siderosis: Prevalence and biomarker profile in a memory clinic population |pdf=|usr=}}{{27534713}} gab.com Text Cortical superficial siderosis: Prevalence and biomarker profile in a memory clinic population JO: Neurology http://www.kidney.de/pget.php?&tw=1&pmid=27534713 #FOAvip Objective:: To gain further insight into cortical superficial siderosis (cSS), a new hemorrhagic neuroimaging marker of cerebral amyloid angiopathy (CAA), and to investigate the clinical, neuroimaging, genetic, and CSF biomarker profile of cSS in a large, consecutive memory clinic series. Methods:: We included 1,504 memory clinic patients undergoing dementia investigation including a brain MRI in our center. Routine CSF biomarker analysis was performed in 1,039 patients and APOE genotyping in 520 patients. MRIs were systematically evaluated for presumed marker of small vessel disease: cSS, cerebral microbleeds, enlarged perivascular spaces, white matter hyperintensities, and lacunes. Results:: cSS was detected in 40 patients (2.7%; 95% confidence interval [CI] 1.9?3.6); cSS was focal in 33 cases (2.2%; 95% CI 1.5?3.1) and disseminated in 7 (0.5%; 95% CI 0.2?1). Vascular dementia had the highest cSS prevalence (13%; 95% CI 5.4?24.9), followed by Alzheimer disease (5%; 95% CI 3.1?7.5). The most commonly affected area was the occipital lobe (70%; 95% CI 53.5?83.4). cSS was associated with lobar cerebral microbleeds (odds ratio [OR] 7.9; 95% CI 3.4?18.1; p < 0.001), high-degree centrum semiovale perivascular spaces (OR 1.7; 95% CI 1.2?2.6; p = 0.008), and white matter hyperintensities (OR 1.5; 95% CI 1.0?2.2; p = 0.062). APOE ?4/4 genotype was more common in cSS cases compared to those without. CSF ?-amyloid 42 was lower in patients with cSS (coefficient ?0.09; 95% CI ?0.15 to ?0.03; p = 0.004). Conclusions:: Our large series of memory clinic patients provides evidence that cSS is related to cerebrovascular disease and may be a manifestation of severe CAA, even in patients without intracerebral hemorrhage. Twit Text FOAVip Cortical superficial siderosis: Prevalence and biomarker profile in a memory clinic population ????Neurology http://www.kidney.de/pget.php?&tw=1&pmid=27534713 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27534713 #FOAvip English Wikipedia <ref>{{Cite pmid|27534713}}</ref> Cortical superficial siderosis: Prevalence and biomarker profile in a memory clinic population #MMPMID27534713 Shams S; Martola J; Charidimou A; Cavallin L; Granberg T; Shams M; Forslin Y; Aspelin P; Kristoffersen-Wiberg M; Wahlund LO Neurology 2016[Sep]; 87 (11): 1110-7 PMID27534713show ga Objective:: To gain further insight into cortical superficial siderosis (cSS), a new hemorrhagic neuroimaging marker of cerebral amyloid angiopathy (CAA), and to investigate the clinical, neuroimaging, genetic, and CSF biomarker profile of cSS in a large, consecutive memory clinic series. Methods:: We included 1,504 memory clinic patients undergoing dementia investigation including a brain MRI in our center. Routine CSF biomarker analysis was performed in 1,039 patients and APOE genotyping in 520 patients. MRIs were systematically evaluated for presumed marker of small vessel disease: cSS, cerebral microbleeds, enlarged perivascular spaces, white matter hyperintensities, and lacunes. Results:: cSS was detected in 40 patients (2.7%; 95% confidence interval [CI] 1.9?3.6); cSS was focal in 33 cases (2.2%; 95% CI 1.5?3.1) and disseminated in 7 (0.5%; 95% CI 0.2?1). Vascular dementia had the highest cSS prevalence (13%; 95% CI 5.4?24.9), followed by Alzheimer disease (5%; 95% CI 3.1?7.5). The most commonly affected area was the occipital lobe (70%; 95% CI 53.5?83.4). cSS was associated with lobar cerebral microbleeds (odds ratio [OR] 7.9; 95% CI 3.4?18.1; p < 0.001), high-degree centrum semiovale perivascular spaces (OR 1.7; 95% CI 1.2?2.6; p = 0.008), and white matter hyperintensities (OR 1.5; 95% CI 1.0?2.2; p = 0.062). APOE ?4/4 genotype was more common in cSS cases compared to those without. CSF ?-amyloid 42 was lower in patients with cSS (coefficient ?0.09; 95% CI ?0.15 to ?0.03; p = 0.004). Conclusions:: Our large series of memory clinic patients provides evidence that cSS is related to cerebrovascular disease and may be a manifestation of severe CAA, even in patients without intracerebral hemorrhage. äCortical superficial siderosis: Prevalence and biomarker profile in a (epmc).pdf DeepDyve Pubget Overpricing