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10.1038/srep33500 http://scihub22266oqcxt.onion/10.1038/srep33500 C5027591!5027591 !27640726     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27640726 &cmd=llinks): Failed to open stream: HTTP request failed! 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SCOP/PHLPP1? in the basolateral amygdala regulates circadian expression of mouse anxiety-like behavior |pdf=|usr=}}{{27640726 }} gab.com Text SCOP/PHLPP1 in the basolateral amygdala regulates circadian expression of mouse anxiety-like behavior JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27640726 #FOAvip While disruption of the circadian clock triggers a spectrum of affective abnormalities, how the clock regulates mammalian emotionality remains unclear. Here, we characterized the time-of-day-dependent regulation of mouse anxiety-like behaviors. We show that anxiety-like behaviors are expressed in a circadian manner in mice and demonstrate that the clock machineries in the dorsal telencephalon (dTel) are required for the time-of-day-dependent regulation of anxiety-like behaviors. We identify suprachiasmatic nucleus circadian oscillatory protein (SCOP/PHLPP1?) as an essential intracellular signaling molecule mediating this temporal regulation downstream of the clock. Using viral-mediated, basolateral amygdala (BLA)-specific knockout of Scop, we demonstrate that deletion of SCOP in the BLA exerts anxiolytic effects on the elevated plus maze at early subjective night, thereby blunting the circadian variation in the anxiety-like behavior. We conclude that the circadian expression of SCOP in the BLA plays a key role in generating circadian rhythmicity in the anxiety-like behavior. Our results demonstrate SCOP as a regulator of anxiety-like behaviors and reveal its key roles in the anxiogenic functions of the BLA. Twit Text FOAVip SCOP/PHLPP1 in the basolateral amygdala regulates circadian expression of mouse anxiety-like behavior ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27640726 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27640726 #FOAvip English Wikipedia <ref>{{Cite pmid|27640726 }}</ref> SCOP/PHLPP1? in the basolateral amygdala regulates circadian expression of mouse anxiety-like behavior #MMPMID27640726 Nakano JJ ; Shimizu K ; Shimba S ; Fukada Y Sci Rep 2016[Sep]; 6 (ä): 33500 PMID27640726 show ga While disruption of the circadian clock triggers a spectrum of affective abnormalities, how the clock regulates mammalian emotionality remains unclear. Here, we characterized the time-of-day-dependent regulation of mouse anxiety-like behaviors. We show that anxiety-like behaviors are expressed in a circadian manner in mice and demonstrate that the clock machineries in the dorsal telencephalon (dTel) are required for the time-of-day-dependent regulation of anxiety-like behaviors. We identify suprachiasmatic nucleus circadian oscillatory protein (SCOP/PHLPP1?) as an essential intracellular signaling molecule mediating this temporal regulation downstream of the clock. Using viral-mediated, basolateral amygdala (BLA)-specific knockout of Scop, we demonstrate that deletion of SCOP in the BLA exerts anxiolytic effects on the elevated plus maze at early subjective night, thereby blunting the circadian variation in the anxiety-like behavior. We conclude that the circadian expression of SCOP in the BLA plays a key role in generating circadian rhythmicity in the anxiety-like behavior. Our results demonstrate SCOP as a regulator of anxiety-like behaviors and reveal its key roles in the anxiogenic functions of the BLA. |*Behavior, Animal [MESH] |*Circadian Rhythm [MESH] |Animals [MESH] |Anxiety/*metabolism [MESH] |Basolateral Nuclear Complex/*metabolism [MESH] |Circadian Clocks [MESH] |Male [MESH] |Maze Learning [MESH] |Mice, Inbred C57BL [MESH] |Nuclear Proteins/genetics/*metabolism [MESH] |Phosphoprotein Phosphatases/genetics/*metabolism [MESH]SCOP/PHLPP1? in the basolateral amygdala regulates circadian expressio(epmc).pdf DeepDyve Pubget Overpricing