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10.1073/pnas.1521069113 http://scihub22266oqcxt.onion/10.1073/pnas.1521069113 C5027463!5027463!27578867     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (37): E5434-43 Nephropedia Template TP {{tp|p=27578867|t=2016. Cd47-Sirp? interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells |pdf=|usr=}}{{27578867}} gab.com Text Cd47-Sirp interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27578867 #FOAvip The present study reveals that macrophage phagocytosis toward healthy self-cells is controlled by a two-tier mechanism: a forefront activation mechanism requiring the inflammatory cytokine-stimulated protein kinase C (PKC)-spleen tyrosine kinase (Syk) pathway, to which IL-10 conversely regulates, and the subsequent self-target discrimination mechanism controlled by the CD47-signal regulatory protein ? (SIRP?)?mediated inhibition. The findings significantly expand our understanding of macrophage phagocytic plasticity and behavior under different conditions and also provide insights into strategies for enhancing transplantation tolerance and macrophage-based cancer eradication, especially for cancers toward which therapeutic antibodies are yet unavailable. Twit Text FOAVip Cd47-Sirp interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27578867 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27578867 #FOAvip English Wikipedia <ref>{{Cite pmid|27578867}}</ref> Cd47-Sirp? interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells #MMPMID27578867 Bian Z; Shi L; Guo YL; Lv Z; Tang C; Niu S; Tremblay A; Venkataramani M; Culpepper C; Li L; Zhou Z; Mansour A; Zhang Y; Gewirtz A; Kidder K; Zen K; Liu Y Proc Natl Acad Sci U S A 2016[Sep]; 113 (37): E5434-43 PMID27578867show ga The present study reveals that macrophage phagocytosis toward healthy self-cells is controlled by a two-tier mechanism: a forefront activation mechanism requiring the inflammatory cytokine-stimulated protein kinase C (PKC)-spleen tyrosine kinase (Syk) pathway, to which IL-10 conversely regulates, and the subsequent self-target discrimination mechanism controlled by the CD47-signal regulatory protein ? (SIRP?)?mediated inhibition. The findings significantly expand our understanding of macrophage phagocytic plasticity and behavior under different conditions and also provide insights into strategies for enhancing transplantation tolerance and macrophage-based cancer eradication, especially for cancers toward which therapeutic antibodies are yet unavailable. äCd47-Sirp? interaction and IL-10 constrain inflammation-induced macrop(epmc).pdf DeepDyve Pubget Overpricing