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10.1073/pnas.1525022113

http://scihub22266oqcxt.onion/10.1073/pnas.1525022113
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C5027408!5027408!27582466
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suck abstract from ncbi


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pmid27582466      Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (37): 10388-93
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  • Long noncoding RNA #32 contributes to antiviral responses by controlling interferon-stimulated gene expression #MMPMID27582466
  • Nishitsuji H; Ujino S; Yoshio S; Sugiyama M; Mizokami M; Kanto T; Shimotohno K
  • Proc Natl Acad Sci U S A 2016[Sep]; 113 (37): 10388-93 PMID27582466show ga
  • Here, we describe a key feature of the long noncoding RNA (lncRNA) involved in innate immunity. We identified 182 lncRNAs that were highly modulated in poly(I:C)-treated hepatocyte cells. Of these, lncRNA#32 regulated the level of IFN-stimulated genes under both unstimulated and type I IFN-stimulated conditions through interactions with hnRNPU and ATF2, and therefore plays an important role in antiviral immunity.
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