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10.1073/pnas.1608069113 http://scihub22266oqcxt.onion/10.1073/pnas.1608069113 C5027407!5027407!27551071     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (37): 10304-9 Nephropedia Template TP {{tp|p=27551071|t=2016. Precision glycocalyx editing as a strategy for cancer immunotherapy |pdf=|usr=}}{{27551071}} gab.com Text Precision glycocalyx editing as a strategy for cancer immunotherapy JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27551071 #FOAvip Successful tumors are able to evade the immune system, which is otherwise capable of killing transformed cells. Therapies that prevent this evasion have become revolutionary treatments for incurable cancers. One mechanism of evasion is the presentation of sugars, called sialic acids, within the cell surface?s sugar coating, or glycocalyx. Here, we designed biotherapeutic molecules, termed ?antibody?enzyme conjugates,? that selectively remove sialic acids from tumor cells. The antibody directs the enzyme to the cancer cells, the enzyme cleaves the sugars, and then the antibody directs immune cells to kill the desialylated cancer cells. The conjugate increased tumor cell killing compared with the antibody alone. Editing the cancer cell glycocalyx with an antibody?enzyme conjugate represents a promising approach to cancer immune therapy. Twit Text FOAVip Precision glycocalyx editing as a strategy for cancer immunotherapy ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27551071 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27551071 #FOAvip English Wikipedia <ref>{{Cite pmid|27551071}}</ref> Precision glycocalyx editing as a strategy for cancer immunotherapy #MMPMID27551071 Xiao H; Woods EC; Vukojicic P; Bertozzi CR Proc Natl Acad Sci U S A 2016[Sep]; 113 (37): 10304-9 PMID27551071show ga Successful tumors are able to evade the immune system, which is otherwise capable of killing transformed cells. Therapies that prevent this evasion have become revolutionary treatments for incurable cancers. One mechanism of evasion is the presentation of sugars, called sialic acids, within the cell surface?s sugar coating, or glycocalyx. Here, we designed biotherapeutic molecules, termed ?antibody?enzyme conjugates,? that selectively remove sialic acids from tumor cells. The antibody directs the enzyme to the cancer cells, the enzyme cleaves the sugars, and then the antibody directs immune cells to kill the desialylated cancer cells. The conjugate increased tumor cell killing compared with the antibody alone. Editing the cancer cell glycocalyx with an antibody?enzyme conjugate represents a promising approach to cancer immune therapy. äPrecision glycocalyx editing as a strategy for cancer immunotherapy (epmc).pdf DeepDyve Pubget Overpricing