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10.14814/phy2.12965 http://scihub22266oqcxt.onion/10.14814/phy2.12965 C5027366!5027366!27624688     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Physiol+Rep 2016 ; 4 (17): ä Nephropedia Template TP {{tp|p=27624688|t=2016. Increased hemoglobin?oxygen affinity ameliorates bleomycin?induced hypoxemia and pulmonary fibrosis |pdf=|usr=}}{{27624688}} gab.com Text Increased hemoglobin oxygen affinity ameliorates bleomycin induced hypoxemia and pulmonary fibrosis JO: Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=27624688 #FOAvip Although exertional dyspnea and worsening hypoxia are hallmark clinical features of idiopathic pulmonary fibrosis (IPF), no drug currently available could treat them. GBT1118 is a novel orally bioavailable small molecule that binds to hemoglobin and produces a concentration?dependent left shift of the oxygen?hemoglobin dissociation curve with subsequent increase in hemoglobin?oxygen affinity and arterial oxygen loading. To assess whether pharmacological modification of hemoglobin?oxygen affinity could ameliorate hypoxemia associated with lung fibrosis, we evaluated GBT1118 in a bleomycin?induced mouse model of hypoxemia and fibrosis. After pulmonary fibrosis and hypoxemia were induced, GBT1118 was administered for eight consecutive days. Hypoxemia was determined by monitoring arterial oxygen saturation, while the severity of pulmonary fibrosis was assessed by histopathological evaluation and determination of collagen and leukocyte levels in bronchoalveolar lavage fluid. We found that hemoglobin modification by GBT1118 had strong antihypoxemic therapeutic effects with improved arterial oxygen saturation to near normal level. Moreover, GBT1118 treatment significantly attenuated bleomycin?induced lung fibrosis, collagen accumulation, body weight loss, and leukocyte infiltration. This study is the first to suggest the beneficial effects of hemoglobin modification in fibrotic lungs and offers a promising and novel therapeutic strategy for the treatment of hypoxemia associated with chronic fibrotic lung disorders in human, including IPF. Twit Text FOAVip Increased hemoglobin oxygen affinity ameliorates bleomycin induced hypoxemia and pulmonary fibrosis ????Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=27624688 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27624688 #FOAvip English Wikipedia <ref>{{Cite pmid|27624688}}</ref> Increased hemoglobin?oxygen affinity ameliorates bleomycin?induced hypoxemia and pulmonary fibrosis #MMPMID27624688 Geng X; Dufu K; Hutchaleelaha A; Xu Q; Li Z; Li C; Patel MP; Vlahakis N; Lehrer?Graiwer J; Oksenberg D Physiol Rep 2016[Sep]; 4 (17): ä PMID27624688show ga Although exertional dyspnea and worsening hypoxia are hallmark clinical features of idiopathic pulmonary fibrosis (IPF), no drug currently available could treat them. GBT1118 is a novel orally bioavailable small molecule that binds to hemoglobin and produces a concentration?dependent left shift of the oxygen?hemoglobin dissociation curve with subsequent increase in hemoglobin?oxygen affinity and arterial oxygen loading. To assess whether pharmacological modification of hemoglobin?oxygen affinity could ameliorate hypoxemia associated with lung fibrosis, we evaluated GBT1118 in a bleomycin?induced mouse model of hypoxemia and fibrosis. After pulmonary fibrosis and hypoxemia were induced, GBT1118 was administered for eight consecutive days. Hypoxemia was determined by monitoring arterial oxygen saturation, while the severity of pulmonary fibrosis was assessed by histopathological evaluation and determination of collagen and leukocyte levels in bronchoalveolar lavage fluid. We found that hemoglobin modification by GBT1118 had strong antihypoxemic therapeutic effects with improved arterial oxygen saturation to near normal level. Moreover, GBT1118 treatment significantly attenuated bleomycin?induced lung fibrosis, collagen accumulation, body weight loss, and leukocyte infiltration. This study is the first to suggest the beneficial effects of hemoglobin modification in fibrotic lungs and offers a promising and novel therapeutic strategy for the treatment of hypoxemia associated with chronic fibrotic lung disorders in human, including IPF. äIncreased hemoglobin?oxygen affinity ameliorates bleomycin?induced hyp(epmc).pdf DeepDyve Pubget Overpricing