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10.14814/phy2.12915 http://scihub22266oqcxt.onion/10.14814/phy2.12915 C5027349!5027349!27582065     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Physiol+Rep 2016 ; 4 (17): ä Nephropedia Template TP {{tp|p=27582065|t=2016. EZH2 enhances the differentiation of fibroblasts into myofibroblasts in idiopathic pulmonary fibrosis |pdf=|usr=}}{{27582065}} gab.com Text EZH2 enhances the differentiation of fibroblasts into myofibroblasts in idiopathic pulmonary fibrosis JO: Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=27582065 #FOAvip The accumulation of fibroblasts/myofibroblasts in fibrotic foci is one of the characteristics of idiopathic pulmonary fibrosis (IPF). Enhancer of zeste homolog 2 (EZH2) is the catalytic component of a multiprotein complex, polycomb repressive complex 2, which is involved in the trimethylation of histone H3 at lysine 27. In this study, we investigated the role and mechanisms of EZH2 in the differentiation of fibroblasts into myofibroblasts. We found that EZH2 was upregulated in the lungs of patients with IPF and in mice with bleomycin?induced lung fibrosis. The upregulation of EZH2 occurred in myofibroblasts. The inhibition of EZH2 by its inhibitor 3?deazaneplanocin A (DZNep) or an shRNA reduced the TGF??1?induced differentiation of human lung fibroblasts into myofibroblasts, as demonstrated by the expression of the myofibroblast markers ??smooth muscle actin and fibronectin, and contractility. DZNep inhibited Smad2/3 nuclear translocation without affecting Smad2/3 phosphorylation. DZNep treatment attenuated bleomycin?induced pulmonary fibrosis in mice. We conclude that EZH2 induces the differentiation of fibroblasts to myofibroblasts by enhancing Smad2/3 nuclear translocation. Twit Text FOAVip EZH2 enhances the differentiation of fibroblasts into myofibroblasts in idiopathic pulmonary fibrosis ????Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=27582065 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27582065 #FOAvip English Wikipedia <ref>{{Cite pmid|27582065}}</ref> EZH2 enhances the differentiation of fibroblasts into myofibroblasts in idiopathic pulmonary fibrosis #MMPMID27582065 Xiao X; Senavirathna LK; Gou X; Huang C; Liang Y; Liu L Physiol Rep 2016[Sep]; 4 (17): ä PMID27582065show ga The accumulation of fibroblasts/myofibroblasts in fibrotic foci is one of the characteristics of idiopathic pulmonary fibrosis (IPF). Enhancer of zeste homolog 2 (EZH2) is the catalytic component of a multiprotein complex, polycomb repressive complex 2, which is involved in the trimethylation of histone H3 at lysine 27. In this study, we investigated the role and mechanisms of EZH2 in the differentiation of fibroblasts into myofibroblasts. We found that EZH2 was upregulated in the lungs of patients with IPF and in mice with bleomycin?induced lung fibrosis. The upregulation of EZH2 occurred in myofibroblasts. The inhibition of EZH2 by its inhibitor 3?deazaneplanocin A (DZNep) or an shRNA reduced the TGF??1?induced differentiation of human lung fibroblasts into myofibroblasts, as demonstrated by the expression of the myofibroblast markers ??smooth muscle actin and fibronectin, and contractility. DZNep inhibited Smad2/3 nuclear translocation without affecting Smad2/3 phosphorylation. DZNep treatment attenuated bleomycin?induced pulmonary fibrosis in mice. We conclude that EZH2 induces the differentiation of fibroblasts to myofibroblasts by enhancing Smad2/3 nuclear translocation. äEZH2 enhances the differentiation of fibroblasts into myofibroblasts i(epmc).pdf DeepDyve Pubget Overpricing