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10.1186/s40168-016-0195-9 http://scihub22266oqcxt.onion/10.1186/s40168-016-0195-9 C5027112!5027112!27640125     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microbiome 2016 ; 4 (ä): ä Nephropedia Template TP {{tp|p=27640125|t=2016. Intestinal microbiota in pediatric patients with end stage renal disease: a Midwest Pediatric Nephrology Consortium study |pdf=|usr=}}{{27640125}} gab.com Text Intestinal microbiota in pediatric patients with end stage renal disease: a Midwest Pediatric Nephrology Consortium study JO: Microbiome http://www.kidney.de/pget.php?&tw=1&pmid=27640125 #FOAvip Background: End-stage renal disease (ESRD) is associated with uremia and increased systemic inflammation. Alteration of the intestinal microbiota may facilitate translocation of endotoxins into the systemic circulation leading to inflammation. We hypothesized that children with ESRD have an altered intestinal microbiota and increased serum levels of bacterially derived uremic toxins. Methods: Four groups of subjects were recruited: peritoneal dialysis (PD), hemodialysis (HD), post-kidney transplant and healthy controls. Stool bacterial composition was assessed by pyrosequencing analysis of 16S rRNA genes. Serum levels of C-reactive protein (CRP), D-lactate, p-cresyl sulfate and indoxyl sulfate were measured. Results: Compared to controls, the relative abundance of Firmicutes (P?=?0.0228) and Actinobacteria (P?=?0.0040) was decreased in PD patients. The relative abundance of Bacteroidetes was increased in HD patients (P?=?0.0462). Compared to HD patients the relative abundance of Proteobacteria (P?=?0.0233) was increased in PD patients. At the family level, Enterobacteriaceae was significantly increased in PD patients (P?=?0.0020) compared to controls; whereas, Bifidobacteria showed a significant decrease in PD and transplant patients (P?=?0.0020) compared to control. Alpha diversity was decreased in PD patients and kidney transplant using both phylogenetic and non-phylogenetic diversity measures (P?=?0.0031 and 0.0003, respectively), while beta diversity showed significant separation (R statistic?=?0.2656, P?=?0.010) between PD patients and controls. ESRD patients had increased serum levels of p-cresyl sulfate and indoxyl sulfate (P?<?0.0001 and P?<?0.0001, respectively). The data suggests that no significant correlation exists between the alpha diversity of the intestinal microbiota and CRP, D-lactate, or uremic toxins. Oral iron supplementation results in expansion of the phylum Proteobacteria. Conclusions: Children with ESRD have altered intestinal microbiota and increased bacterially derived serum uremic toxins. Twit Text FOAVip Intestinal microbiota in pediatric patients with end stage renal disease: a Midwest Pediatric Nephrology Consortium study ????Microbiome http://www.kidney.de/pget.php?&tw=1&pmid=27640125 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27640125 #FOAvip English Wikipedia <ref>{{Cite pmid|27640125}}</ref> Intestinal microbiota in pediatric patients with end stage renal disease: a Midwest Pediatric Nephrology Consortium study #MMPMID27640125 Crespo-Salgado J; Vehaskari VM; Stewart T; Ferris M; Zhang Q; Wang G; Blanchard EE; Taylor CM; Kallash M; Greenbaum LA; Aviles DH Microbiome 2016[]; 4 (ä): ä PMID27640125show ga Background: End-stage renal disease (ESRD) is associated with uremia and increased systemic inflammation. Alteration of the intestinal microbiota may facilitate translocation of endotoxins into the systemic circulation leading to inflammation. We hypothesized that children with ESRD have an altered intestinal microbiota and increased serum levels of bacterially derived uremic toxins. Methods: Four groups of subjects were recruited: peritoneal dialysis (PD), hemodialysis (HD), post-kidney transplant and healthy controls. Stool bacterial composition was assessed by pyrosequencing analysis of 16S rRNA genes. Serum levels of C-reactive protein (CRP), D-lactate, p-cresyl sulfate and indoxyl sulfate were measured. Results: Compared to controls, the relative abundance of Firmicutes (P?=?0.0228) and Actinobacteria (P?=?0.0040) was decreased in PD patients. The relative abundance of Bacteroidetes was increased in HD patients (P?=?0.0462). Compared to HD patients the relative abundance of Proteobacteria (P?=?0.0233) was increased in PD patients. At the family level, Enterobacteriaceae was significantly increased in PD patients (P?=?0.0020) compared to controls; whereas, Bifidobacteria showed a significant decrease in PD and transplant patients (P?=?0.0020) compared to control. Alpha diversity was decreased in PD patients and kidney transplant using both phylogenetic and non-phylogenetic diversity measures (P?=?0.0031 and 0.0003, respectively), while beta diversity showed significant separation (R statistic?=?0.2656, P?=?0.010) between PD patients and controls. ESRD patients had increased serum levels of p-cresyl sulfate and indoxyl sulfate (P? äIntestinal microbiota in pediatric patients with end stage renal disea(epmc).pdf DeepDyve Pubget Overpricing