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2016 ; 45
(6
): 761-7
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Different Risk Indictors of Diabetic Nephropathy in Transforming Growth
Factor-beta1 T869C CC/CT Genotype and TT Genotype
#MMPMID27648419
Mou X
; Liu Y
; Zhou D
; Hu Y
; Ma G
; Shou C
; Chen J
; Zhou D
Iran J Public Health
2016[Jun]; 45
(6
): 761-7
PMID27648419
show ga
BACKGROUND: Transforming growth factor-beta 1(TGF-?1) T869C (rs1800470, the same
below) gene polymorphism is notably relative with the development of Diabetic
Nephropathy (DN), and CC/CT genotype diabetic have higher frequency of than TT
genotype diabetic. To find out individual risk factors in the two genotypes
especially in susceptible genotype could provide more efficient and targeted
prevention. METHODS: This was a prospective cohort study. A total of 251 type 2
diabetes mellitus (T2DM) patients [53.4% male, 56(52-67) years] were enrolled in
this cohort study. Multiple concerned factors were collected and the relationship
of these risk factors and development of DN were evaluated by Cox regression
analysis. Hazard ratios of development of DN were calculated by Kaplan-Meier
curves and the Cox proportional hazards model for CC/CT genotype versus TT
genotype patients. RESULTS: TGF-?1 T869C gene polymorphism was an independent
predictor of DN in T2DM patients (HR, 2.08; 95%CI, 1.18-3.66; P=0.012).
Hyperlipemia (HR, 1.91; 95%CI, 1.19-3.08; P=0.007), age (HR, 0.95; 95%CI,
0.93-0.98; P=0.001) and smoking status (HR, 2.36; 95%CI, 1.07-5.21; P=0.033) were
risk indictors of the development of DN in CC/CT genotype patients. HbA1c (HR,
2.8; 95%CI, 1.07-7.30; P=0.036), hypertension (HR, 7.46; 95%CI, 1.38-40.29;
P=0.02), and hyperlipemia (HR, 12.33; 95%CI, 1.05-145.39; P=0.046) were risk
indictors for the development of DN in TT genotype patients. CONCLUSION: TGF-?1
T869C gene polymorphism was an independent predictor of DN for T2DM patients and
CC/CT genotype had higher susceptibility to DN. CC/CT genotype and TT genotype
patients had different risk indictors of DN.
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