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10.1016/j.phrs.2016.07.005 http://scihub22266oqcxt.onion/10.1016/j.phrs.2016.07.005 C5026593!5026593 !27394167     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27394167 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Pharmacol+Res 2016 ; 111 (ä): 413-421 Nephropedia Template TP {{tp|p=27394167 |t=2016. A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells |pdf=|usr=}}{{27394167 }} gab.com Text A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells JO: Pharmacol Res http://www.kidney.de/pget.php?&tw=1&pmid=27394167 #FOAvip Cancer cells have high rates of glycolysis and lactic acid fermentation in order to fuel accelerated rates of cell division (Warburg effect). Here, we present a strategy for merging cancer and yeast metabolism to remove pyruvate, a key intermediate of cancer cell metabolism, and produce the toxic compound acetaldehyde. This approach was achieved by administering the yeast enzyme pyruvate decarboxylase to triple negative breast cancer cells. To overcome the challenges of protein delivery, a nanoparticle-based system consisting of cationic lipids and porous silicon were employed to obtain efficient intracellular uptake. The results demonstrate that the enzyme therapy decreases cancer cell viability through production of acetaldehyde and reduction of lactic acid fermentation. Twit Text FOAVip A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells ????Pharmacol Res http://www.kidney.de/pget.php?&tw=1&pmid=27394167 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27394167 #FOAvip English Wikipedia <ref>{{Cite pmid|27394167 }}</ref> A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells #MMPMID27394167 Scott B ; Shen J ; Nizzero S ; Boom K ; Persano S ; Mi Y ; Liu X ; Zhao Y ; Blanco E ; Shen H ; Ferrari M ; Wolfram J Pharmacol Res 2016[Sep]; 111 (ä): 413-421 PMID27394167 show ga Cancer cells have high rates of glycolysis and lactic acid fermentation in order to fuel accelerated rates of cell division (Warburg effect). Here, we present a strategy for merging cancer and yeast metabolism to remove pyruvate, a key intermediate of cancer cell metabolism, and produce the toxic compound acetaldehyde. This approach was achieved by administering the yeast enzyme pyruvate decarboxylase to triple negative breast cancer cells. To overcome the challenges of protein delivery, a nanoparticle-based system consisting of cationic lipids and porous silicon were employed to obtain efficient intracellular uptake. The results demonstrate that the enzyme therapy decreases cancer cell viability through production of acetaldehyde and reduction of lactic acid fermentation. |Acetaldehyde/metabolism [MESH] |Antineoplastic Agents/chemistry/isolation & purification/*pharmacology [MESH] |Cell Line, Tumor [MESH] |Cell Survival/drug effects [MESH] |Drug Carriers [MESH] |Drug Compounding [MESH] |Energy Metabolism/*drug effects [MESH] |Female [MESH] |Fermentation [MESH] |Glycolysis [MESH] |Humans [MESH] |Lactic Acid/metabolism [MESH] |Lipids/chemistry [MESH] |Nanoparticles [MESH] |Porosity [MESH] |Pyruvate Decarboxylase/chemistry/isolation & purification/*pharmacology [MESH] |Saccharomyces cerevisiae Proteins/chemistry/isolation & purification/*pharmacology [MESH] |Saccharomyces cerevisiae/*enzymology [MESH] |Silicon/chemistry [MESH]A pyruvate decarboxylase-mediated therapeutic strategy for mimicking y(epmc).pdf DeepDyve Pubget Overpricing