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2016 ; 157
(3
): 461-74
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Human breast cancer biopsies induce eosinophil recruitment and enhance adjacent
cancer cell proliferation
#MMPMID27249999
Szalayova G
; Ogrodnik A
; Spencer B
; Wade J
; Bunn J
; Ambaye A
; James T
; Rincon M
Breast Cancer Res Treat
2016[Jun]; 157
(3
): 461-74
PMID27249999
show ga
Chronic inflammation is known to facilitate cancer progression and metastasis.
Less is known about the effect of acute inflammation within the tumor
microenvironment, resulting from standard invasive procedures. Recent studies in
mouse models have shown that the acute inflammatory response triggered by a
biopsy in mammary cancer increases the frequency of distal metastases. Although
tumor biopsies are part of the standard clinical practice in breast cancer
diagnosis, no studies have reported their effect on inflammatory response. The
objective of this study is to (1) determine whether core needle biopsies in
breast cancer patients trigger an inflammatory response, (2) characterize the
type of inflammatory response present, and (3) evaluate the potential effect of
any acute inflammatory response on residual tumor cells. The biopsy wound site
was identified in the primary tumor resection tissue samples from breast cancer
patients. The inflammatory response in areas adjacent (i.e., immediately around
previous biopsy site) and distant to the wound biopsy was investigated by
histology and immunohistochemistry analysis. Proliferation of tumor cells was
also assayed. We demonstrate that diagnostic core needle biopsies trigger a
selective recruitment of inflammatory cells at the site of the biopsy, and they
persist for extended periods of time. While macrophages were part of the
inflammatory response, an unexpected accumulation of eosinophils at the edge of
the biopsy wound was also identified. Importantly, we show that biopsy causes an
increase in the proliferation rate of tumor cells located in the area adjacent to
the biopsy wound. Diagnostic core needle biopsies in breast cancer patients do
induce a unique acute inflammatory response within the tumor microenvironment and
have an effect on the surrounding tumor cells. Therefore, biopsy-induced
inflammation could have an impact on residual tumor cell progression and/or
metastasis in human breast cancer. These findings may carry relevance in the
clinical management of breast cancer.
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