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10.1016/j.chom.2016.08.002 http://scihub22266oqcxt.onion/10.1016/j.chom.2016.08.002 C5026396!5026396!27631700     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27631700&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Host+Microbe 2016 ; 20 (3): 329-41 Nephropedia Template TP {{tp|p=27631700|t=2016. STING requires the adaptor TRIF to trigger innate immune responses to microbial infection |pdf=|usr=}}{{27631700}} gab.com Text STING requires the adaptor TRIF to trigger innate immune responses to microbial infection JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=27631700 #FOAvip The intracellular microbial nucleic acid sensors, TLR3 and STING, recognize pathogen molecules and signal to activate the interferon pathway. The TIR-domain containing protein TRIF is the sole adaptor of TLR3. Here we report an essential role for TRIF in STING signaling: various activators of STING could not induce genes in the absence of TRIF. TRIF and STING interacted directly, through their carboxyl terminal domains, to promote STING dimerization, intermembrane translocation and signaling. Herpes simplex virus (HSV), which triggers the STING signaling pathway and is controlled by it, replicated more efficiently in the absence of TRIF and HSV-infected TRIF?/? mice displayed pronounced pathology. Our results indicate that defective STING signaling may be responsible for the observed genetic association between TRIF mutations and Herpes Simplex Encephalitis in patients. Twit Text FOAVip STING requires the adaptor TRIF to trigger innate immune responses to microbial infection ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=27631700 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27631700 #FOAvip English Wikipedia <ref>{{Cite pmid|27631700}}</ref> STING requires the adaptor TRIF to trigger innate immune responses to microbial infection #MMPMID27631700 Wang X; Majumdar T; Kessler P; Ozhegov E; Zhang Y; Chattopadhyay S; Barik S; Sen GC Cell Host Microbe 2016[Sep]; 20 (3): 329-41 PMID27631700show ga The intracellular microbial nucleic acid sensors, TLR3 and STING, recognize pathogen molecules and signal to activate the interferon pathway. The TIR-domain containing protein TRIF is the sole adaptor of TLR3. Here we report an essential role for TRIF in STING signaling: various activators of STING could not induce genes in the absence of TRIF. TRIF and STING interacted directly, through their carboxyl terminal domains, to promote STING dimerization, intermembrane translocation and signaling. Herpes simplex virus (HSV), which triggers the STING signaling pathway and is controlled by it, replicated more efficiently in the absence of TRIF and HSV-infected TRIF?/? mice displayed pronounced pathology. Our results indicate that defective STING signaling may be responsible for the observed genetic association between TRIF mutations and Herpes Simplex Encephalitis in patients. äSTING requires the adaptor TRIF to trigger innate immune responses to (epmc).pdf DeepDyve Pubget Overpricing