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10.1016/j.bbalip.2015.08.002 http://scihub22266oqcxt.onion/10.1016/j.bbalip.2015.08.002 C5026326!5026326!26253821     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Biophys+Acta 2015 ; 1851 (11): 1482-9 Nephropedia Template TP {{tp|p=26253821|t=2015. Regulation of ceramide generation during macrophage apoptosis by ASMase and de novo synthesis |pdf=|usr=}}{{26253821}} gab.com Text Regulation of ceramide generation during macrophage apoptosis by ASMase and de novo synthesis JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=26253821 #FOAvip The survival of macrophages depends on the presence of specific cytokines that activate survival signalling events, as well as suppressing formation of apoptosis-inducing pathways. We have previously shown that macrophages deprived of macrophage colony stimulating factor (M-CSF) produce ceramide that contributes to apoptosis of these cells, a pathway that is suppressed by exposure to oxidized LDL. In this study we have examined macrophages derived from mice lacking acid acid sphingomyelinase (ASMase) to ask whether these events are altered due to the impaired ability of these cells to break down sphingomyelin and produce ceramide. We found that these cells do survive better than cells from wild type mice, but they still undergo cell death and some ceramide is formed. We show that the ceramide is being produced by a de novo synthetic pathway. Therefore, ceramide production in M-CSF-deprived macrophages arises from a combination of ASMase activity and de novo synthesis. Twit Text FOAVip Regulation of ceramide generation during macrophage apoptosis by ASMase and de novo synthesis ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=26253821 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26253821 #FOAvip English Wikipedia <ref>{{Cite pmid|26253821}}</ref> Regulation of ceramide generation during macrophage apoptosis by ASMase and de novo synthesis #MMPMID26253821 Wang SW; Hojabrpour P; Kolesnick RN; Steinbrecher UP; Gómez-Muñoz A; Duronio V Biochim Biophys Acta 2015[Nov]; 1851 (11): 1482-9 PMID26253821show ga The survival of macrophages depends on the presence of specific cytokines that activate survival signalling events, as well as suppressing formation of apoptosis-inducing pathways. We have previously shown that macrophages deprived of macrophage colony stimulating factor (M-CSF) produce ceramide that contributes to apoptosis of these cells, a pathway that is suppressed by exposure to oxidized LDL. In this study we have examined macrophages derived from mice lacking acid acid sphingomyelinase (ASMase) to ask whether these events are altered due to the impaired ability of these cells to break down sphingomyelin and produce ceramide. We found that these cells do survive better than cells from wild type mice, but they still undergo cell death and some ceramide is formed. We show that the ceramide is being produced by a de novo synthetic pathway. Therefore, ceramide production in M-CSF-deprived macrophages arises from a combination of ASMase activity and de novo synthesis. äRegulation of ceramide generation during macrophage apoptosis by ASMas(epmc).pdf DeepDyve Pubget Overpricing