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2016 ; 116
(ä): 357-74
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English Wikipedia
Epithelial Skin Biology: Three Decades of Developmental Biology, a Hundred
Questions Answered and a Thousand New Ones to Address
#MMPMID26970628
Fuchs E
Curr Top Dev Biol
2016[]; 116
(ä): 357-74
PMID26970628
show ga
The mammalian skin epidermis and its hair and sweat gland appendages provide a
protective barrier that retains essential body fluids, guards against invasion by
harmful microbes, and regulates body temperature through the ability to sweat. At
the interface between the external environment and the body, skin is constantly
subjected to physical trauma and must also be primed to repair wounds in response
to injury. In adults, the skin maintains epidermal homeostasis, hair
regeneration, and wound repair through the use of its stem cells. This essay
focuses on when stem cells become established during skin development and where
these cells reside in adult epithelial tissues of the skin. I explore how skin
stem cells maintain tissue homeostasis and repair wounds and how they regulate
the delicate balance between proliferation and differentiation. Finally, I tackle
the relation between skin cancer and mutations that perturb the regulation of
stem cells.