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10.1038/srep33327 http://scihub22266oqcxt.onion/10.1038/srep33327 C5025891!5025891 !27633952     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27633952 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 33327 Nephropedia Template TP {{tp|p=27633952 |t=2016. A diverse virome in kidney transplant patients contains multiple viral subtypes with distinct polymorphisms |pdf=|usr=}}{{27633952 }} gab.com Text A diverse virome in kidney transplant patients contains multiple viral subtypes with distinct polymorphisms JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27633952 #FOAvip Recent studies have established that the human urine contains a complex microbiome, including a virome about which little is known. Following immunosuppression in kidney transplant patients, BK polyomavirus (BKV) has been shown to induce nephropathy (BKVN), decreasing graft survival. In this study we investigated the urine virome profile of BKV+ and BKV- kidney transplant recipients. Virus-like particles were stained to confirm the presence of VLP in the urine samples. Metagenomic DNA was purified, and the virome profile was analyzed using metagenomic shotgun sequencing. While the BK virus was predominant in the BKV+ group, it was also found in the BKV- group patients. Additional viruses were also detected in all patients, notably including JC virus (JCV) and Torque teno virus (TTV) and interestingly, we detected multiple subtypes of the BKV, JCV and TTV. Analysis of the BKV subtypes showed that nucleotide polymorphisms were detected in the VP1, VP2 and Large T Antigen proteins, suggesting potential functional effects for enhanced pathogenicity. Our results demonstrate a complex urinary virome in kidney transplant patients with multiple viruses with several distinct subtypes warranting further analysis of virus subtypes in immunosuppressed hosts. Twit Text FOAVip A diverse virome in kidney transplant patients contains multiple viral subtypes with distinct polymorphisms ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27633952 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27633952 #FOAvip English Wikipedia <ref>{{Cite pmid|27633952 }}</ref> A diverse virome in kidney transplant patients contains multiple viral subtypes with distinct polymorphisms #MMPMID27633952 Rani A ; Ranjan R ; McGee HS ; Metwally A ; Hajjiri Z ; Brennan DC ; Finn PW ; Perkins DL Sci Rep 2016[Sep]; 6 (ä): 33327 PMID27633952 show ga Recent studies have established that the human urine contains a complex microbiome, including a virome about which little is known. Following immunosuppression in kidney transplant patients, BK polyomavirus (BKV) has been shown to induce nephropathy (BKVN), decreasing graft survival. In this study we investigated the urine virome profile of BKV+ and BKV- kidney transplant recipients. Virus-like particles were stained to confirm the presence of VLP in the urine samples. Metagenomic DNA was purified, and the virome profile was analyzed using metagenomic shotgun sequencing. While the BK virus was predominant in the BKV+ group, it was also found in the BKV- group patients. Additional viruses were also detected in all patients, notably including JC virus (JCV) and Torque teno virus (TTV) and interestingly, we detected multiple subtypes of the BKV, JCV and TTV. Analysis of the BKV subtypes showed that nucleotide polymorphisms were detected in the VP1, VP2 and Large T Antigen proteins, suggesting potential functional effects for enhanced pathogenicity. Our results demonstrate a complex urinary virome in kidney transplant patients with multiple viruses with several distinct subtypes warranting further analysis of virus subtypes in immunosuppressed hosts. |*Immunocompromised Host [MESH] |*Kidney Transplantation [MESH] |Adult [MESH] |Aged [MESH] |BK Virus/classification/*genetics/isolation & purification [MESH] |Cohort Studies [MESH] |DNA Virus Infections/diagnosis/immunology/virology [MESH] |DNA, Viral/*genetics [MESH] |Female [MESH] |Genotype [MESH] |Humans [MESH] |Immunosuppressive Agents/administration & dosage [MESH] |JC Virus/classification/*genetics/isolation & purification [MESH] |Kidney Failure, Chronic/surgery/therapy [MESH] |Male [MESH] |Metagenome [MESH] |Middle Aged [MESH] |Phylogeny [MESH] |Polymorphism, Genetic [MESH] |Polyomavirus Infections/diagnosis/immunology/virology [MESH] |Sequence Analysis, DNA [MESH] |Torque teno virus/classification/*genetics/isolation & purification [MESH] |Tumor Virus Infections/diagnosis/immunology/virology [MESH]A diverse virome in kidney transplant patients contains multiple viral(epmc).pdf DeepDyve Pubget Overpricing