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10.1038/ncomms12596 http://scihub22266oqcxt.onion/10.1038/ncomms12596 C5025763!5025763!27581382     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=27581382|t=2016. Bach2?Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop |pdf=|usr=}}{{27581382}} gab.com Text Bach2 Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27581382 #FOAvip Although Bach2 has an important role in regulating the Th2-type immune response, the underlying molecular mechanisms remain unclear. We herein demonstrate that Bach2 associates with Batf and binds to the regulatory regions of the Th2 cytokine gene loci. The Bach2?Batf complex antagonizes the recruitment of the Batf?Irf4 complex to AP-1 motifs and suppresses Th2 cytokine production. Furthermore, we find that Bach2 regulates the Batf and Batf3 expressions via two distinct pathways. First, Bach2 suppresses the maintenance of the Batf and Batf3 expression through the inhibition of IL-4 production. Second, the Bach2?Batf complex directly binds to the Batf and Batf3 gene loci and reduces transcription by interfering with the Batf?Irf4 complex. These findings suggest that IL-4 and Batf form a positive feedback amplification loop to induce Th2 cell differentiation and the subsequent Th2-type immune response, and Bach2?Batf interactions are required to prevent an excessive Th2 response. Twit Text FOAVip Bach2 Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27581382 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27581382 #FOAvip English Wikipedia <ref>{{Cite pmid|27581382}}</ref> Bach2?Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop #MMPMID27581382 Kuwahara M; Ise W; Ochi M; Suzuki J; Kometani K; Maruyama S; Izumoto M; Matsumoto A; Takemori N; Takemori A; Shinoda K; Nakayama T; Ohara O; Yasukawa M; Sawasaki T; Kurosaki T; Yamashita M Nat Commun 2016[]; 7 (ä): ä PMID27581382show ga Although Bach2 has an important role in regulating the Th2-type immune response, the underlying molecular mechanisms remain unclear. We herein demonstrate that Bach2 associates with Batf and binds to the regulatory regions of the Th2 cytokine gene loci. The Bach2?Batf complex antagonizes the recruitment of the Batf?Irf4 complex to AP-1 motifs and suppresses Th2 cytokine production. Furthermore, we find that Bach2 regulates the Batf and Batf3 expressions via two distinct pathways. First, Bach2 suppresses the maintenance of the Batf and Batf3 expression through the inhibition of IL-4 production. Second, the Bach2?Batf complex directly binds to the Batf and Batf3 gene loci and reduces transcription by interfering with the Batf?Irf4 complex. These findings suggest that IL-4 and Batf form a positive feedback amplification loop to induce Th2 cell differentiation and the subsequent Th2-type immune response, and Bach2?Batf interactions are required to prevent an excessive Th2 response. äBach2?Batf interactions control Th2-type immune response by regulating(epmc).pdf DeepDyve Pubget Overpricing