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10.1074/jbc.M115.700070 http://scihub22266oqcxt.onion/10.1074/jbc.M115.700070 C5025685!5025685 !27489109     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27489109 &cmd=llinks): Failed to open stream: HTTP request failed! 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Chaperonin-containing T-complex Protein 1 Subunit ? Serves as an Autoantigen Recognized by Human V?2 ?? T Cells in Autoimmune Diseases |pdf=|usr=}}{{27489109 }} gab.com Text Chaperonin-containing T-complex Protein 1 Subunit Serves as an Autoantigen Recognized by Human V 2 T Cells in Autoimmune Diseases JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27489109 #FOAvip Human ?? T cells recognize conserved endogenous and stress-induced antigens typically associated with autoimmune diseases. However, the role of ?? T cells in autoimmune diseases is not clear. Few autoimmune disease-related antigens recognized by T cell receptor (TCR) ?? have been defined. In this study, we compared V?2 TCR complementarity-determining region 3 (CDR3) between systemic lupus erythematosus (SLE) patients and healthy donors. Results show that CDR3 length distribution differed significantly and displayed oligoclonal characteristics in SLE patients when compared with healthy donors. We found no difference in the frequency of J? gene fragment usage between these two groups. According to the dominant CDR3? sequences in SLE patients, synthesized SL2 peptides specifically bound to human renal proximal tubular epithelial cell line HK-2; SL2-Vm, a mutant V sequence of SL2, did not bind. We identified the putative protein ligand chaperonin-containing T-complex protein 1 subunit ? (CCT6A) using SL2 as a probe in HK-2 cell protein extracts by affinity chromatography and liquid chromatography-electrospray ionization-tandem mass spectrometry analysis. We found CCT6A expression on the surface of HK-2 cells. Cytotoxicity of only V?2 ?? T cells to HK-2 cells was blocked by anti-CCT6A antibody. Finally, we note that CCT6A concentration was significantly increased in plasma of SLE and rheumatoid arthritis patients. These data suggest that CCT6A is a novel autoantigen recognized by V?2 ?? T cells, which deepens our understanding of mechanisms in autoimmune diseases. Twit Text FOAVip Chaperonin-containing T-complex Protein 1 Subunit Serves as an Autoantigen Recognized by Human V 2 T Cells in Autoimmune Diseases ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27489109 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27489109 #FOAvip English Wikipedia <ref>{{Cite pmid|27489109 }}</ref> Chaperonin-containing T-complex Protein 1 Subunit ? Serves as an Autoantigen Recognized by Human V?2 ?? T Cells in Autoimmune Diseases #MMPMID27489109 Chen H ; You H ; Wang L ; Zhang X ; Zhang J ; He W J Biol Chem 2016[Sep]; 291 (38 ): 19985-93 PMID27489109 show ga Human ?? T cells recognize conserved endogenous and stress-induced antigens typically associated with autoimmune diseases. However, the role of ?? T cells in autoimmune diseases is not clear. Few autoimmune disease-related antigens recognized by T cell receptor (TCR) ?? have been defined. In this study, we compared V?2 TCR complementarity-determining region 3 (CDR3) between systemic lupus erythematosus (SLE) patients and healthy donors. Results show that CDR3 length distribution differed significantly and displayed oligoclonal characteristics in SLE patients when compared with healthy donors. We found no difference in the frequency of J? gene fragment usage between these two groups. According to the dominant CDR3? sequences in SLE patients, synthesized SL2 peptides specifically bound to human renal proximal tubular epithelial cell line HK-2; SL2-Vm, a mutant V sequence of SL2, did not bind. We identified the putative protein ligand chaperonin-containing T-complex protein 1 subunit ? (CCT6A) using SL2 as a probe in HK-2 cell protein extracts by affinity chromatography and liquid chromatography-electrospray ionization-tandem mass spectrometry analysis. We found CCT6A expression on the surface of HK-2 cells. Cytotoxicity of only V?2 ?? T cells to HK-2 cells was blocked by anti-CCT6A antibody. Finally, we note that CCT6A concentration was significantly increased in plasma of SLE and rheumatoid arthritis patients. These data suggest that CCT6A is a novel autoantigen recognized by V?2 ?? T cells, which deepens our understanding of mechanisms in autoimmune diseases. |Adult [MESH] |Aged [MESH] |Autoantigens/genetics/*immunology [MESH] |Cell Line [MESH] |Chaperonin Containing TCP-1/genetics/*immunology [MESH] |Complementarity Determining Regions/genetics/*immunology [MESH] |Female [MESH] |Gene Expression Regulation/*immunology [MESH] |Humans [MESH] |Lupus Erythematosus, Systemic/genetics/*immunology [MESH] |Male [MESH] |Middle Aged [MESH]Chaperonin-containing T-complex Protein 1 Subunit ? Serves as an Autoa(epmc).pdf DeepDyve Pubget Overpricing