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10.1038/srep33676 http://scihub22266oqcxt.onion/10.1038/srep33676 C5025656!5025656 !27633396     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27633396 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 33676 Nephropedia Template TP {{tp|p=27633396 |t=2016. Silencing of Histone Deacetylase 9 Expression in Podocytes Attenuates Kidney Injury in Diabetic Nephropathy |pdf=|usr=}}{{27633396 }} gab.com Text Silencing of Histone Deacetylase 9 Expression in Podocytes Attenuates Kidney Injury in Diabetic Nephropathy JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27633396 #FOAvip Podocyte dysfunction is important in the onset and development of diabetic nephropathy (DN). Histone deacetylases (HDACs) have been recently proved to play critical roles in the pathogenesis of DN. As one subtype of the class IIa HDACs, HDAC9 is capable to repress/de-repress their target genes in tumor, inflammation, atherosclerosis and metabolic diseases. In the present study, we investigate whether HDAC9 is involved in the pathophysiologic process of DN, especially the podocyte injury. Firstly, we explored the expression patterns and localization of HDAC9 and found that HDAC9 expression was significantly up-regulated in high glucose (HG)-treated mouse podocytes, as well as kidney tissues from diabetic db/db mice and patients with DN. Secondly, knockdown of HDAC9 in mouse podocytes significantly suppressed HG-induced reactive oxygen species (ROS) generation, cell apoptosis and inflammation through JAK2/STAT3 pathway and reduced the podocytes injury by decreasing the expression levels of Nephrin and Podocin. Moreover, in diabetic db/db mice, silencing of HDAC9 attenuated the glomerulosclerosis, inflammatory cytokine release, podocyte apoptosis and renal injury. Collectively, these data indicate that HDAC9 may be involved in the process of DN, especially podocyte injury. Our study suggest that inhibition of HDAC9 may have a therapeutic potential in DN treatment. Twit Text FOAVip Silencing of Histone Deacetylase 9 Expression in Podocytes Attenuates Kidney Injury in Diabetic Nephropathy ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27633396 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27633396 #FOAvip English Wikipedia <ref>{{Cite pmid|27633396 }}</ref> Silencing of Histone Deacetylase 9 Expression in Podocytes Attenuates Kidney Injury in Diabetic Nephropathy #MMPMID27633396 Liu F ; Zong M ; Wen X ; Li X ; Wang J ; Wang Y ; Jiang W ; Li X ; Guo Z ; Qi H Sci Rep 2016[Sep]; 6 (ä): 33676 PMID27633396 show ga Podocyte dysfunction is important in the onset and development of diabetic nephropathy (DN). Histone deacetylases (HDACs) have been recently proved to play critical roles in the pathogenesis of DN. As one subtype of the class IIa HDACs, HDAC9 is capable to repress/de-repress their target genes in tumor, inflammation, atherosclerosis and metabolic diseases. In the present study, we investigate whether HDAC9 is involved in the pathophysiologic process of DN, especially the podocyte injury. Firstly, we explored the expression patterns and localization of HDAC9 and found that HDAC9 expression was significantly up-regulated in high glucose (HG)-treated mouse podocytes, as well as kidney tissues from diabetic db/db mice and patients with DN. Secondly, knockdown of HDAC9 in mouse podocytes significantly suppressed HG-induced reactive oxygen species (ROS) generation, cell apoptosis and inflammation through JAK2/STAT3 pathway and reduced the podocytes injury by decreasing the expression levels of Nephrin and Podocin. Moreover, in diabetic db/db mice, silencing of HDAC9 attenuated the glomerulosclerosis, inflammatory cytokine release, podocyte apoptosis and renal injury. Collectively, these data indicate that HDAC9 may be involved in the process of DN, especially podocyte injury. Our study suggest that inhibition of HDAC9 may have a therapeutic potential in DN treatment. |*Gene Silencing/drug effects [MESH] |Animals [MESH] |Apoptosis/drug effects [MESH] |Diabetic Nephropathies/complications/*enzymology/genetics/pathology [MESH] |Gene Knockdown Techniques [MESH] |Glucose/toxicity [MESH] |Histone Deacetylases/*genetics/metabolism [MESH] |Inflammation/pathology [MESH] |Intracellular Signaling Peptides and Proteins/metabolism [MESH] |Janus Kinase 2/metabolism [MESH] |Kidney/*injuries/pathology [MESH] |Male [MESH] |Matrix Metalloproteinases/metabolism [MESH] |Membrane Proteins/metabolism [MESH] |Mice, Inbred C57BL [MESH] |Phosphorylation/drug effects [MESH] |Podocytes/drug effects/*enzymology/pathology [MESH] |Protein Kinase Inhibitors/pharmacology [MESH] |RNA, Messenger/genetics/metabolism [MESH] |Reactive Oxygen Species/metabolism [MESH] |Repressor Proteins/*genetics/metabolism [MESH] |STAT3 Transcription Factor/metabolism [MESH] |Signal Transduction/drug effects [MESH]Silencing of Histone Deacetylase 9 Expression in Podocytes Attenuates (epmc).pdf DeepDyve Pubget Overpricing