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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Appl+Health+Econ+Health+Policy
2016 ; 14
(5
): 515-26
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The Urolift System for the Treatment of Lower Urinary Tract Symptoms Secondary to
Benign Prostatic Hyperplasia: A NICE Medical Technology Guidance
#MMPMID26832146
Ray A
; Morgan H
; Wilkes A
; Carter K
; Carolan-Rees G
Appl Health Econ Health Policy
2016[Oct]; 14
(5
): 515-26
PMID26832146
show ga
As part of its Medical Technologies Evaluation Programme (MTEP), the National
Institute for Health and Care Excellence (NICE) invited Neotract (manufacturer)
to submit clinical and economic evidence for their prostatic urethral lift
device, Urolift, for the relief of lower urinary tract symptoms secondary to
benign prostatic hyperplasia (LUTS BPH). The Urolift System uses implants to
retract the prostatic lobe away from the urethral lumen. The clinical evidence
used in the manufacturer's submission shows that Urolift is effective for the
treatment of BPH. Urolift delivers a weighted mean International Prostate Symptom
Score (IPSS) improvement of between 9.22 and 11.82 points. These Urolift
improvements are greater than a published 'marked improvement' in IPSS score of
8.80. Comparison with randomised controlled trials (RCTs) of TURP (Transurethral
Resection of Prostate) and HoLEP (Holmium Laser Enucleation of Prostate) show
that Urolift does not yield better clinical outcomes from baseline compared to
TURP and HoLEP in terms of IPSS, QoL (Quality of Life) and Qmax (maximum urinary
flow). However, Urolift appears to have the advantage in terms of minimal and
mild complications, and this may be of interest to patients and urologists. The
economic case for Urolift was made using a very detailed and thorough de novo
cost model. The base case posed by the manufacturer placed Urolift at almost
cost-neutral (£3 cost incurring, based on 2014 prices) compared to TURP, and £418
cost incurring compared to HoLEP. In an additional scenario comparing day-case
Urolift with in-patient TURP, the estimated per-patient savings with Urolift were
£286 compared with monopolar TURP (mTURP) and £159 compared with bipolar TURP
(BiTURP). NICE guidance MTG26 recommends that the case for adoption of Urolift
was supported by the evidence, when implemented in a day-case setting.