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10.1007/s12016-016-8540-0 http://scihub22266oqcxt.onion/10.1007/s12016-016-8540-0 C5025506!5025506!27122021     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Rev+Allergy+Immunol 2016 ; 51 (2): 152-61 Nephropedia Template TP {{tp|p=27122021|t=2016. Bradykinin: Inflammatory Product of the Coagulation System |pdf=|usr=}}{{27122021}} gab.com Text Bradykinin: Inflammatory Product of the Coagulation System JO: Clin Rev Allergy Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27122021 #FOAvip Episodic and recurrent local cutaneous or mucosal swelling are key features of angioedema. The vasoactive agents histamine and bradykinin are highly implicated as mediators of these swelling attacks. It is challenging to assess the contribution of bradykinin to the clinical expression of angioedema, as accurate biomarkers for the generation of this vasoactive peptide are still lacking. In this review, we will describe the mechanisms that are responsible for bradykinin production in hereditary angioedema (HAE) and the central role that the coagulation factor XII (FXII) plays in it. Evidently, several plasma parameters of coagulation change during attacks of HAE and may prove valuable biomarkers for disease activity. We propose that these changes are secondary to vascular leakage, rather than a direct consequence of FXII activation. Furthermore, biomarkers for fibrinolytic system activation (i.e. plasminogen activation) also change during attacks of HAE. These changes may reflect triggering of the bradykinin-forming mechanisms by plasmin. Finally, multiple lines of evidence suggest that neutrophil activation and mast-cell activation are functionally linked to bradykinin production. We put forward the paradigm that FXII functions as a ?sensor molecule? to detect conditions that require bradykinin release via crosstalk with cell-derived enzymes. Understanding the mechanisms that drive bradykinin generation may help to identify angioedema patients that have bradykinin-mediated disease and could benefit from a targeted treatment. Twit Text FOAVip Bradykinin: Inflammatory Product of the Coagulation System ????Clin Rev Allergy Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27122021 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27122021 #FOAvip English Wikipedia <ref>{{Cite pmid|27122021}}</ref> Bradykinin: Inflammatory Product of the Coagulation System #MMPMID27122021 Hofman Z; de Maat S; Hack CE; Maas C Clin Rev Allergy Immunol 2016[]; 51 (2): 152-61 PMID27122021show ga Episodic and recurrent local cutaneous or mucosal swelling are key features of angioedema. The vasoactive agents histamine and bradykinin are highly implicated as mediators of these swelling attacks. It is challenging to assess the contribution of bradykinin to the clinical expression of angioedema, as accurate biomarkers for the generation of this vasoactive peptide are still lacking. In this review, we will describe the mechanisms that are responsible for bradykinin production in hereditary angioedema (HAE) and the central role that the coagulation factor XII (FXII) plays in it. Evidently, several plasma parameters of coagulation change during attacks of HAE and may prove valuable biomarkers for disease activity. We propose that these changes are secondary to vascular leakage, rather than a direct consequence of FXII activation. Furthermore, biomarkers for fibrinolytic system activation (i.e. plasminogen activation) also change during attacks of HAE. These changes may reflect triggering of the bradykinin-forming mechanisms by plasmin. Finally, multiple lines of evidence suggest that neutrophil activation and mast-cell activation are functionally linked to bradykinin production. We put forward the paradigm that FXII functions as a ?sensor molecule? to detect conditions that require bradykinin release via crosstalk with cell-derived enzymes. Understanding the mechanisms that drive bradykinin generation may help to identify angioedema patients that have bradykinin-mediated disease and could benefit from a targeted treatment. äBradykinin: Inflammatory Product of the Coagulation System (epmc).pdf DeepDyve Pubget Overpricing