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10.1016/j.chom.2016.07.019 http://scihub22266oqcxt.onion/10.1016/j.chom.2016.07.019 C5025396!5025396!27593514     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Host+Microbe 2016 ; 20 (3): 307-17 Nephropedia Template TP {{tp|p=27593514|t=2016. Streptococcus pneumoniae senses a human-like sialic acid profile via the response regulator CiaR |pdf=|usr=}}{{27593514}} gab.com Text Streptococcus pneumoniae senses a human-like sialic acid profile via the response regulator CiaR JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=27593514 #FOAvip Streptococcus pneumoniae is a human-adapted pathogen that encounters terminally sialylated glycoconjugates and free sialic acid (Sia) in the airways. Upon scavenging by the bacterial sialidase NanA, Sia products serve as carbon sources for the bacteria. Unlike most animals in which cytidine-monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts Sia N-acetylneuraminic acid (Neu5Ac) into N-glycolylneuraminic acid (Neu5Gc), humans have an inactive CMAH, causing an absence of Neu5Gc and excess Neu5Ac. We find that pneumococcal challenge in Cmah?/? mice leads to heightened bacterial loads, virulence, and NanA expression. In vitro, NanA is upregulated in response to Neu5Ac compared to Neu5Gc, a process controlled by two-component response regulator CiaR and requiring Sia uptake by the transporter SatABC. Additionally, compared to Neu5Gc, Neu5Ac increases pneumococcal resistance to antimicrobial reactive oxygen species in a CiaR-dependant manner. Thus, S. pneumoniae senses and responds to Neu5Ac, leading to CiaR activation and increased virulence and potentially explaining greater susceptibility in humans. Twit Text FOAVip Streptococcus pneumoniae senses a human-like sialic acid profile via the response regulator CiaR ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=27593514 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27593514 #FOAvip English Wikipedia <ref>{{Cite pmid|27593514}}</ref> Streptococcus pneumoniae senses a human-like sialic acid profile via the response regulator CiaR #MMPMID27593514 Hentrich K; Löfling J; Pathak A; Nizet V; Varki A; Henriques-Normark B Cell Host Microbe 2016[Sep]; 20 (3): 307-17 PMID27593514show ga Streptococcus pneumoniae is a human-adapted pathogen that encounters terminally sialylated glycoconjugates and free sialic acid (Sia) in the airways. Upon scavenging by the bacterial sialidase NanA, Sia products serve as carbon sources for the bacteria. Unlike most animals in which cytidine-monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts Sia N-acetylneuraminic acid (Neu5Ac) into N-glycolylneuraminic acid (Neu5Gc), humans have an inactive CMAH, causing an absence of Neu5Gc and excess Neu5Ac. We find that pneumococcal challenge in Cmah?/? mice leads to heightened bacterial loads, virulence, and NanA expression. In vitro, NanA is upregulated in response to Neu5Ac compared to Neu5Gc, a process controlled by two-component response regulator CiaR and requiring Sia uptake by the transporter SatABC. Additionally, compared to Neu5Gc, Neu5Ac increases pneumococcal resistance to antimicrobial reactive oxygen species in a CiaR-dependant manner. Thus, S. pneumoniae senses and responds to Neu5Ac, leading to CiaR activation and increased virulence and potentially explaining greater susceptibility in humans. äStreptococcus pneumoniae senses a human-like sialic acid profile via t(epmc).pdf DeepDyve Pubget Overpricing