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10.1091/mbc.E16-06-0429 http://scihub22266oqcxt.onion/10.1091/mbc.E16-06-0429 C5025271!5025271 !27440924     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27440924 &cmd=llinks): Failed to open stream: HTTP request failed! 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Formin-mediated actin polymerization at cell-cell junctions stabilizes E-cadherin and maintains monolayer integrity during wound repair |pdf=|usr=}}{{27440924 }} gab.com Text Formin-mediated actin polymerization at cell-cell junctions stabilizes E-cadherin and maintains monolayer integrity during wound repair JO: Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=27440924 #FOAvip Cadherin-mediated cell-cell adhesion is required for epithelial tissue integrity in homeostasis, during development, and in tissue repair. E-cadherin stability depends on F-actin, but the mechanisms regulating actin polymerization at cell-cell junctions remain poorly understood. Here we investigated a role for formin-mediated actin polymerization at cell-cell junctions. We identify mDia1 and Fmnl3 as major factors enhancing actin polymerization and stabilizing E-cadherin at epithelial junctions. Fmnl3 localizes to adherens junctions downstream of Src and Cdc42 and its depletion leads to a reduction in F-actin and E-cadherin at junctions and a weakening of cell-cell adhesion. Of importance, Fmnl3 expression is up-regulated and junctional localization increases during collective cell migration. Depletion of Fmnl3 or mDia1 in migrating monolayers results in dissociation of leader cells and impaired wound repair. In summary, our results show that formin activity at epithelial cell-cell junctions is important for adhesion and the maintenance of epithelial cohesion during dynamic processes, such as wound repair. Twit Text FOAVip Formin-mediated actin polymerization at cell-cell junctions stabilizes E-cadherin and maintains monolayer integrity during wound repair ????Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=27440924 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27440924 #FOAvip English Wikipedia <ref>{{Cite pmid|27440924 }}</ref> Formin-mediated actin polymerization at cell-cell junctions stabilizes E-cadherin and maintains monolayer integrity during wound repair #MMPMID27440924 Rao MV ; Zaidel-Bar R Mol Biol Cell 2016[Sep]; 27 (18 ): 2844-56 PMID27440924 show ga Cadherin-mediated cell-cell adhesion is required for epithelial tissue integrity in homeostasis, during development, and in tissue repair. E-cadherin stability depends on F-actin, but the mechanisms regulating actin polymerization at cell-cell junctions remain poorly understood. Here we investigated a role for formin-mediated actin polymerization at cell-cell junctions. We identify mDia1 and Fmnl3 as major factors enhancing actin polymerization and stabilizing E-cadherin at epithelial junctions. Fmnl3 localizes to adherens junctions downstream of Src and Cdc42 and its depletion leads to a reduction in F-actin and E-cadherin at junctions and a weakening of cell-cell adhesion. Of importance, Fmnl3 expression is up-regulated and junctional localization increases during collective cell migration. Depletion of Fmnl3 or mDia1 in migrating monolayers results in dissociation of leader cells and impaired wound repair. In summary, our results show that formin activity at epithelial cell-cell junctions is important for adhesion and the maintenance of epithelial cohesion during dynamic processes, such as wound repair. |Actin Cytoskeleton/metabolism [MESH] |Actins/metabolism [MESH] |Adherens Junctions/metabolism [MESH] |Animals [MESH] |Cadherins/*metabolism/physiology [MESH] |Carrier Proteins/metabolism [MESH] |Cell Adhesion [MESH] |Cell Line [MESH] |Cell Movement [MESH] |Epithelial Cells/metabolism [MESH] |Epithelium/metabolism [MESH] |Fetal Proteins/metabolism [MESH] |Formins [MESH] |Intercellular Junctions/metabolism [MESH] |Mice [MESH] |Microfilament Proteins/metabolism [MESH] |Nuclear Proteins/metabolism [MESH] |Polymerization [MESH] |Proteins/*metabolism [MESH] |Wound Healing/physiology [MESH]Formin-mediated actin polymerization at cell-cell junctions stabilizes(epmc).pdf DeepDyve Pubget Overpricing