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10.1371/journal.pone.0160560 http://scihub22266oqcxt.onion/10.1371/journal.pone.0160560 C5025241!5025241!27632355     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2016 ; 11 (9): ä Nephropedia Template TP {{tp|p=27632355|t=2016. Antibiotic Treatment for First Episode of Acute Otitis Media Is Not Associated with Future Recurrences |pdf=|usr=}}{{27632355}} gab.com Text Antibiotic Treatment for First Episode of Acute Otitis Media Is Not Associated with Future Recurrences JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27632355 #FOAvip Objective: Antibiotic treatment of acute otitis media (AOM) has been suggested to increase the risk of future AOM episodes by causing unfavorable shifts in microbial flora. Because current evidence on this topic is inconclusive and long-term follow-up data are scarce, we wanted to estimate the effect of antibiotic treatment for a first AOM episode occurring during infancy on AOM recurrences and AOM-related health care utilization later in life. Methods: We obtained demographic information and risk factors from data of the Wheezing Illnesses Study Leidsche Rijn, a prospective birth cohort study in which all healthy newborns born in Leidsche Rijn (between 2001 and 2012), The Netherlands, were enrolled. These data were linked to children?s primary care electronic health records up to the age of four. Children with at least one family physician-diagnosed AOM episode before the age of two were included in analyses. The exposure of interest was the prescription of oral antibiotics (yes vs no) for a child?s first AOM episode before the age of two years. Results: 848 children were included in analyses and 512 (60%) children were prescribed antibiotics for their first AOM episode. Antibiotic treatment was not associated with an increased risk of total AOM recurrences (adjusted rate ratio: 0.94, 95% CI: 0.78?1.13), recurrent AOM (?3 episodes in 6 months or ?4 in one year; adjusted risk ratio: 0.79, 95% CI: 0.57?1.11), or with increased AOM-related health care utilization during children?s first four years of life. Conclusions: Oral antibiotic treatment of a first AOM episode occurring during infancy does not affect the number of AOM recurrences and AOM-related health care utilization later in life. This information can be used when weighing the pros and cons of various AOM treatment options. Twit Text FOAVip Antibiotic Treatment for First Episode of Acute Otitis Media Is Not Associated with Future Recurrences ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27632355 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27632355 #FOAvip English Wikipedia <ref>{{Cite pmid|27632355}}</ref> Antibiotic Treatment for First Episode of Acute Otitis Media Is Not Associated with Future Recurrences #MMPMID27632355 te Molder M; de Hoog MLA; Uiterwaal CSPM; van der Ent CK; Smit HA; Schilder AGM; Damoiseaux RAMJ; Venekamp RP PLoS One 2016[]; 11 (9): ä PMID27632355show ga Objective: Antibiotic treatment of acute otitis media (AOM) has been suggested to increase the risk of future AOM episodes by causing unfavorable shifts in microbial flora. Because current evidence on this topic is inconclusive and long-term follow-up data are scarce, we wanted to estimate the effect of antibiotic treatment for a first AOM episode occurring during infancy on AOM recurrences and AOM-related health care utilization later in life. Methods: We obtained demographic information and risk factors from data of the Wheezing Illnesses Study Leidsche Rijn, a prospective birth cohort study in which all healthy newborns born in Leidsche Rijn (between 2001 and 2012), The Netherlands, were enrolled. These data were linked to children?s primary care electronic health records up to the age of four. Children with at least one family physician-diagnosed AOM episode before the age of two were included in analyses. The exposure of interest was the prescription of oral antibiotics (yes vs no) for a child?s first AOM episode before the age of two years. Results: 848 children were included in analyses and 512 (60%) children were prescribed antibiotics for their first AOM episode. Antibiotic treatment was not associated with an increased risk of total AOM recurrences (adjusted rate ratio: 0.94, 95% CI: 0.78?1.13), recurrent AOM (?3 episodes in 6 months or ?4 in one year; adjusted risk ratio: 0.79, 95% CI: 0.57?1.11), or with increased AOM-related health care utilization during children?s first four years of life. Conclusions: Oral antibiotic treatment of a first AOM episode occurring during infancy does not affect the number of AOM recurrences and AOM-related health care utilization later in life. This information can be used when weighing the pros and cons of various AOM treatment options. äAntibiotic Treatment for First Episode of Acute Otitis Media Is Not As(epmc).pdf DeepDyve Pubget Overpricing